Gait variability at fast-pace walking speed: A biomarker of mild cognitive impairment?
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The interpretation of the increase in stride-to-stride variability of stride time (STV) regarding the evolution of cognitive deficits across the dementia spectrum is matter of debate.
The aim of this study was to compare STV at usual and fast-pace walking speeds of MCI patients with that of cognitively healthy individuals (CHI) and Alzheimer’s disease (AD) patients with mild dementia, while considering the effects of potential confounders.
STV while walking at usual and fast-pace walking speeds was recorded with the GAITRite® system from 116 older adults (mean age 75.6±6.5 years; 55.2% female) divided into 3 groups according to their cognitive status (44 CHI, 39 MCI patients and 33 AD patients with mild dementia).
The full adjusted multiple linear regression models showed that high STV was associated with slow gait speed at usual-pace walking speed (P=0.002) and with the MCI status at fast-pace walking speed (P=0.015).
High STV at fast-pace walking speed was a specific gait disturbance of MCI patients in the sample of studied participants, and thus could be used in the future as a specific biomarker of MCI patients.
- Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented participants: Interests and perspectives. Neuropsychiatr Dis Treat. 2008;4:155–160. CrossRef
- Verghese J, Wang C, Lipton RB, Holtzer R, Xue X. Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 2007;78:929–935. CrossRef
- Verghese J, Robbins M, Holtzer R, Zimmerman M, Wang C, Xue X. Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc. 2008;56:1244–1251. CrossRef
- Goldman WP, Baty JD, Buckles VD, Sahrmann S, Morris JC. Motor dysfunction in mildly demented AD individuals without extrapyramidal signs. Neurology 1999;53:956–962. CrossRef
- Kluger A, Gianutsos JG, Golomb J, Ferris SH, George AE, Franssen E. Patterns of motor impairement in normal aging, mild cognitive decline, and early Alzheimer’s disease. J Gerontol B Psychol Sci Soc Sci. 1997;52:P28–39. CrossRef
- Allali G, Assal F, Kressig RW, Dubost V, Herrmann FR, Beauchet O. Impact of impaired executive function on gait stability. Dement Geriatr Cogn Disord. 2008;26:364–369. CrossRef
- Beauchet O, Allali G, Annweiler C, Bridenbaugh S, Assal F, Kressig RW. Gait variability among healthy adults: low and high stride-to-stride variability are both a reflection of gait stability. Gerontology 2009; 55: 702–706. CrossRef
- Beauchet O, Annweiler C, Lecordroch Y, Allali G, Dubost V, Herrmann FR. Walking speed-related changes in stride time variability: effects of decreased speed. J Neuroeng Rehabil. 2009;6:32. CrossRef
- Poujol L, Annweiler C, Allali G, Fantino B, Beauchet O. Effect of psychoactive medication on gait variability in community-dwelling older adults: a cross-sectional study. J Am Geriatr Soc. 2010;58:1207–1208. CrossRef
- Beauchet O, Annweiler C, Lecordroch Y, Allali G, Dubost V, Herrmann FR, Kressig RW. Walking speed-related changes in stride time variability: effects of decreased speed. J Neuroeng Rehabil. 2009;6:32. CrossRef
- Dubost V, Annweiler C, Aminian K, Najafi B, Herrmann FR, Beauchet O. Stride-tostride variability while enumerating animal names among healthy young adults: result of stride velocity or effect of attention-demanding task? Gait Posture. 2008;27:138–143 CrossRef
- Kressig RW, Beauchet O. Guidelines for clinical applications of spatio-temporal gait analysis in older adults. Aging Clin Exp Res. 2006;18:174–176
- Annweiler C, Schott AM, Montero-Odasso M, Berrut G, Fantino B, Herrmann FR, Beauchet O. Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res. 2010;25:1858–1866. CrossRef
- Annweiler C, Fantino B, Schott AM, Krolak-Salmon P, Allali G, Beauchet O. Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. Eur J Neurol. 2012;19:1023–1029. CrossRef
- Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198. CrossRef
- Shah A, Herbert R, Lewis S, Mahendran R, Platt J, Bhattacharyya B. Screening for depression among acutely ill geriatric inpatients with a short Geriatric Depression Scale. Age Ageing 1997;26:217–221. CrossRef
- Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology, 2000; 55:1621–1626. CrossRef
- Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer’s disease. Am J Psychiatry 1984; 141:1356–1364.
- Brown EC, Casey A, Fisch RI, Neuringer C. Trail making test as a screening device for the detection of brain damage. J Consult Psychol. 1958;22:469–474. CrossRef
- Grober E, Buschke H, Crystal H, Bang S, Dresner R. Screening for dementia by memory testing. Neurology. 1988;38:900–903. CrossRef
- Van der Linden M, Coyette F, Poitrenaud F, Kalafat M, Calicis F, Adam, F. L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI-16). In L’évaluation des troubles de la mémoire, (ed. Solal ), 2004, Marseille.
- Pérès K, Chrysostome V, Fabrigoule C, Orgogozo JM, Dartigues JF, Barberger-Gateau P. Restriction in complex activities of daily living in MCI: impact on outcome. Neurology 2006;67:461–466. CrossRef
- Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO. Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256:240–246. CrossRef
- McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944. CrossRef
- Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55:967–972. CrossRef
- Rosano C, Brach J, Studenski S, Longstreth WT, Jr., Newman AB. Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults. Neuroepidemiology 2007;29:193–200. CrossRef
- Zimmerman ME, Lipton RB, Pan JW, Hetherington HP, Verghese J. MRI- and MRS-derived hippocampal correlates of quantitative locomotor function in older adults. Brain Res. 2009;1291:73–81. CrossRef
- Scherder E, Eggermont L, Swaab D, van Heuvelen M, Kamsma Y, de Greef M. Gait in ageing and associated dementias; its relationship with cognition. Neurosci Biobehav Rev 2007;31:485–497. CrossRef
- Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer’s disease: insights from functional MRI studies. Neuropsychologia 2008;46:1624–1635. CrossRef
- Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P. Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol. 2011;9:1118–1127. CrossRef
- Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDSADRDA criteria. Lancet Neurol. 2007;6:734–746. CrossRef
- Gait variability at fast-pace walking speed: A biomarker of mild cognitive impairment?
The journal of nutrition, health & aging
Volume 17, Issue 3 , pp 235-239
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Alzheimer’s disease
- mild cognitive impairment
- gait disorders
- stride-to-stride variability of stride time
- Industry Sectors
- Author Affiliations
- 1394. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France
- 4394. UPRES EA 2646, University of Angers, UNAM, Angers, France
- 5394. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933, Angers Cedex 9, France
- 2394. Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland
- 3394. Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland