The journal of nutrition, health & aging

, Volume 16, Issue 1, pp 40–54

The hormonal pathway to cognitive impairment in older men

Authors

    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • E. Dall’Aglio
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • F. Lauretani
    • Geriatric Unit and Laboratory of Movement Analysis, Geriatric-Rehabilitation, DepartmentUniversity Hospital
  • C. Cattabiani
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • G. Ceresini
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • P. Caffarra
    • Department of NeuroscienceUniversity of Parma
    • Clinical Neuroscience CentreUniversity of Hull
  • G. Valenti
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • R. Volpi
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • A. Vignali
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • G. Schiavi
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
  • G. P. Ceda
    • Department of Internal Medicine and Biomedical Sciences, Section of GeriatricsUniversity of Parma
    • Geriatric Unit and Laboratory of Movement Analysis, Geriatric-Rehabilitation, DepartmentUniversity Hospital
Hormonal Dysregulation and Cognition in the Elderly

DOI: 10.1007/s12603-012-0002-7

Cite this article as:
Maggio, M., Dall’Aglio, E., Lauretani, F. et al. J Nutr Health Aging (2012) 16: 40. doi:10.1007/s12603-012-0002-7
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Abstract

In older men there is a multiple hormonal dysregulation with a relative prevalence of catabolic hormones such as thyroid hormones and cortisol and a decline in anabolic hormones such as dehydroepiandrosterone sulphate, testosterone and insulin like growth factor 1 levels. Many studies suggest that this catabolic milieu is an important predictor of frailty and mortality in older persons. There is a close relationship between frailty and cognitive impairment with studies suggesting that development of frailty is consequence of cognitive impairment and others pointing out that physical frailty is a determinant of cognitive decline. Decline in cognitive function, typically memory, is a major symptom of dementia. The “preclinical phase” of cognitive impairment occurs many years before the onset of dementia. The identification of relevant modifiable factors, including the hormonal dysregulation, may lead to therapeutic strategies for preventing the cognitive dysfunction. There are several mechanisms by which anabolic hormones play a role in neuroprotection and neuromodulation. These hormones facilitate recovery after brain injury and attenuate the neuronal loss. In contrast, elevated thyroid hormones may increase oxidative stress and apoptosis, leading to neuronal damage or death. In this mini review we will address the relationship between low levels of anabolic hormones, changes in thyroid hormones and cognitive function in older men. Then, giving the contradictory data of the literature and the multi-factorial origin of dementia, we will introduce the hypothesis of multiple hormonal derangement as a better determinant of cognitive decline in older men.

Key words

Hormonal dysregulationcognitive impairmentolder men
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Copyright information

© Serdi and Springer Verlag France 2012