Tea and cognitive health in late life: Current evidence and future directions
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This review summarizes the literature on the association between tea consumption and cognitive health in late life. Population-based studies reviewed in this article suggest that tea drinking has beneficial effects on cognitive function of elderly persons. However, a cause-effect relationship between tea consumption and cognitive decline and dementia could not be drawn given inconsistent findings from only two longitudinal cohort studies. The neuroprotective effects of tea consumption could be due to catechins, L-theanine and other compounds in tea leaves. More longitudinal observational study is needed. Information on life-time tea consumption and blood concentrations of catechins and L-theanine could be collected in future studies.
- Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112–2117. CrossRef
- Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology 2007;29:125–132. CrossRef
- Schneider LS. Ginkgo biloba Extract and Preventing Alzheimer Disease. JAMA 2008;300:2306–2308. CrossRef
- Kaye J. Ginkgo biloba Prevention Trials: More Than an Ounce of Prevention Learned. Arch Neurol 2009;66:652–654. CrossRef
- Feng L. Ginkgo biloba and Cognitive Decline. JAMA 2010;303:1477–. CrossRef
- Cheng TO. All teas are not created equal: the Chinese green tea and cardiovascular health. Int J Cardiol 2006;108:301–308. CrossRef
- Lin Y-S, Tsai Y-J, Tsay J-S, Lin J-K. Factors Affecting the Levels of Tea Polyphenols and Caffeine in Tea Leaves. Journal of Agricultural and Food Chemistry 2003;51:1864–1873. CrossRef
- Jöbstl E, Howse JR, Fairclough JPA, Williamson MP. Noncovalent Cross-Linking of Casein by Epigallocatechin Gallate Characterized by Single Molecule Force Microscopy. Journal of Agricultural and Food Chemistry 2006;54:4077–4081. CrossRef
- Niu K, Hozawa A, Kuriyama S, et al. Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr 2009;90:1615–1622. CrossRef
- Khan N, Mukhtar H. Tea polyphenols for health promotion. Life Sci 2007;81:519–533. CrossRef
- Nakachi K, Eguchi H, Imai K. Can teatime increase one’s lifetime? Ageing Res Rev 2003;2:1–10. CrossRef
- Arab L, Liu W, Elashoff D. Green and Black Tea Consumption and Risk of Stroke: A Meta-Analysis. Stroke 2009;40:1786–1792. CrossRef
- Kuriyama S, Hozawa A, Ohmori K, et al. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. Am J Clin Nutr 2006;83:355–361.
- Ng TP, Feng L, Niti M, Kua EH, Yap KB. Tea consumption and cognitive impairment and decline in older Chinese adults. Am J Clin Nutr 2008;88:224–231.
- Feng L, Gwee X, Kua EH, Ng TP. Cognitive function and tea consumption in community dwelling older Chinese in Singapore. J Nutr Health Aging 2010;14:433–438. CrossRef
- Huang C-Q, Dong B-R, Zhang Y-L, Wu H-M, Liu Q-X. Association of Cognitive Impairment With Smoking, Alcohol Consumption, Tea Consumption, and Exercise Among Chinese Nonagenarians/Centenarians. Cognitive and Behavioral Neurology 2009;22:190–196 10.1097/WNN.0b013e3181b2790b. CrossRef
- Nurk E, Refsum H, Drevon CA, et al. Intake of Flavonoid-Rich Wine, Tea, and Chocolate by Elderly Men and Women Is Associated with Better Cognitive Test Performance. J. Nutr. 2009;139:120–127.
- Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198. CrossRef
- Ng T-P, Niti M, Chiam P-C, Kua E-H. Ethnic and Educational Differences in Cognitive Test Performance on Mini-Mental State Examination in Asians. Am. J. Geriatr. Psychiatry 2007;15:130–139. CrossRef
- Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study. Journal of Alzheimer’s Disease 2009;16:85–91.
- Qiu C, Xu W, Fratiglioni L. Vascular and psychosocial factors in Alzheimer’s disease: epidemiological evidence toward intervention. J Alzheimers Dis 2010;20:689–697.
- Yaffe K, Fiocco AJ, Lindquist K, et al. Predictors of maintaining cognitive function in older adults: The Health ABC Study. Neurology 2009;72:2029–2035. CrossRef
- Scarmeas N, Luchsinger JA, Schupf N, et al. Physical Activity, Diet, and Risk of Alzheimer Disease. JAMA 2009;302:627–637. CrossRef
- Mandel SA, Amit T, Kalfon L, Reznichenko L, Youdim MBH. Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins. J. Nutr. 2008;138:1578S–1583.
- Yan X, Zhang J-j, Li X, Lei Z, Dong S, Hui L. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. The Journal of Nutritional Biochemistry 2010;21:741–748. CrossRef
- Chen W-Q, Zhao X-L, Hou Y, et al. Protective effects of green tea polyphenols on cognitive impairments induced by psychological stress in rats. Behavioural Brain Research 2009;202:71–76. CrossRef
- Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade. Neuroscience 2009;159:1208–1215. CrossRef
- Rezai-Zadeh K, Shytle D, Sun N, et al. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice. J. Neurosci. 2005;25:8807–8814. CrossRef
- Rezai-Zadeh K, Arendash GW, Hou H, et al. Green tea epigallocatechin-3-gallate (EGCG) reduces [beta]-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Research 2008;1214:177–187. CrossRef
- Ehrnhoefer DE, Bieschke J, Boeddrich A, et al. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol 2008;15:558–566. CrossRef
- Okello EJ, Savelev SU, Perry EK. In vitro anti-beta-secretase and dual anticholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytother Res 2004;18:624–7. CrossRef
- Bastianetto S, Yao ZX, Papadopoulos V, Quirion R. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci 2006;23:55–64. CrossRef
- de la Torre JC. The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond. Neurodegenerative Diseases 2010;7:116–121. CrossRef
- de la Torre JC. Is Alzheimer’s disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. The Lancet Neurology 2004;3:184–190. CrossRef
- Moorhouse P, Rockwood K. Vascular cognitive impairment: current concepts and clinical developments. The Lancet Neurology 2008;7:246–255. CrossRef
- Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother 2006;6:21–30.
- Kakuda T. Neuroprotective effects of the green tea components theanine and catechins. Biol Pharm Bull 2002;25:1513–8. CrossRef
- Kim TI, Lee YK, Park SG, et al. l-Theanine, an amino acid in green tea, attenuates [beta]-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-[kappa]B pathways. Free Radical Biology and Medicine 2009;47:1601–1610. CrossRef
- Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of Ltheanine, caffeine and their combination on cognition and mood. Biol Psychol 2008;77:113–122. CrossRef
- Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci 2008;11:193–198. CrossRef
- Tea and cognitive health in late life: Current evidence and future directions
The journal of nutrition, health & aging
Volume 16, Issue 1 , pp 31-34
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- cognitive decline
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- Author Affiliations
- 1. Department of Psychiatry, Shengli Hospital of Shengli Oilfield, Shandong, Dongying, China
- 2. Imaging Center, Shengli Hospital of Shengli Oilfield, Shandong, Dongying, China
- 3. Department of Biological Sciences, National University of Singapore, Singapore, Singapore
- 4. Department of Psychological Medicine, National University of Singapore, Singapore, Singapore
- 5. Department of Psychological Medicine, National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore