The journal of nutrition, health & aging

, Volume 16, Issue 2, pp 155–161

Effect of an 8-weeks aerobic training program in elderly on oxidative stress and Hsp72 expression in leukocytes during antioxidant supplementation

Authors

    • School of Medical Sciences, Faculty of MedicineUniversity of New South Wales
    • School of Medical Science, Faculty of MedicineUniversity of New South Wales
  • D. Malatesta
    • INSERM, ERI 25 “Muscle and Pathologies”Hôpital A. de Villeneuve
    • Institute of Sport Sciences (ISSUL), Department of Physiology, Faculty of Biology and MedicineUniversity of Lausanne
  • E. Mas
    • Département de BiochimieHôpital Lapeyronie
  • M. Delage
    • Département de BiochimieHôpital Lapeyronie
  • C. Caillaud
    • Exercise, Health & Performance Research Group, Faculty of Health SciencesThe University of Sydney
JNHA: Clinical Trials and Aging

DOI: 10.1007/s12603-011-0106-5

Cite this article as:
Simar, D., Malatesta, D., Mas, E. et al. J Nutr Health Aging (2012) 16: 155. doi:10.1007/s12603-011-0106-5

Abstract

Objective

To investigate the effect of aerobic training in the context of antioxidant supplementation on systemic oxidative stress and leukocytes heat shock protein (Hsp)72 expression in the elderly.

Design

Sixteen septuagenarians (8 males and 8 females, mean age 74.6) were supplemented with Vitamin C and E (respectively 500 and 100mg per day) and randomly assigned either to sedentary (AS) or individualized aerobically trained (AT) group for 8 weeks.

Methods

Plasma Vitamin C and E concentrations and aerobic fitness, as well as resting and post graded exercise (GXT) Hsp72 expression in leukocytes, plasma levels of thiobarbituric acid reactive substances (TBARS) and advanced oxidation protein product (AOPP) were measured pre and post training / supplementation.

Results

At the end of the intervention, the two groups showed a significant increase in resting plasma vitamin C and E (approximately 50 and 20% increase respectively) and a significant decrease in both resting and post GXT plasma TBARS and AOPP (approximately 25 and 20% decrease respectively). These changes were of similar magnitude in the two groups. The reduced oxidative stress was concomitant with a 15% decreased expression of Hsp72 in monocytes and granulocytes in both groups.

Conclusion

This study provides evidence that in elderly, increased concentration of antioxidant vitamins C and E is associated with a reduction in oxidative stress and leukocytes Hsp72. In this context, 8 weeks of aerobic training has no impact on oxidative stress or leukocytes Hsp72 expression in elderly people.

Key words

AgingOxidative damageHeat shock proteinsPhysical activityVitamins
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Copyright information

© Serdi and Springer Verlag France 2012