The Five-Times-Sit-to-stand test, a marker of global cognitive functioning among community-dwelling older women

  • Cédric Annweiler
  • A. -M. Schott
  • G. Abellan Van Kan
  • Y. Rolland
  • H. Blain
  • B. Fantino
  • F. R. Herrmann
  • O. Beauchet
JNHA: Clinical Neurosciences

DOI: 10.1007/s12603-011-0037-1

Cite this article as:
Annweiler, C., Schott, A.M., Abellan Van Kan, G. et al. J Nutr Health Aging (2011) 15: 271. doi:10.1007/s12603-011-0037-1

Abstract

Objective

To determine whether there was an association between the Five-Times-Sit-to-Stand test (FTSS) and the global cognitive function assessed with Short-Portable-Mental-State-Questionnaire (SPMSQ) among the EPIDOS cohort.

Design

Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.

Setting

Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse.

Participants

7421 community-dwelling older women (mean age 80.41±0.04 years).

Measurements

Time to achieve FTSS, and SPMSQ score. Age, body mass index, high number of comorbidities, cardiovascular risk factors, depression, regular physical activity, joint pain, quadriceps strength, visual acuity, use of psychoactive drugs, serum albumin, vitamin D deficiency (i.e., serum concentration <10ng/mL), and the influence of seasons and study centers were used as covariables. Subjects were divided into 2 groups according to SPMSQ score (either impaired < 8/10 or normal ≥ 8/10).

Results

Compared to their counterparts, the women with cognitive impairment (n=1190, mean 81.51±0.45years) took more time in performing FTSS (17.8±0.9seconds versus 16.1±0.3seconds, P < 0.001). There was a significant negative association of SPMSQ score with FTSS (Unadjusted β=−0.02(95%CI −0.03;−0.01), P<0.001; Fully Adjusted β=−0.03(95%CI −0.05;−0.01), P=0.003; Stepwise Backward Adjusted β=−0.02(95%CI −0.04;−0.01), P=0.005), as well as with advance in age (β=−0.04, P=0.006) and vitamin D deficiency (β=−0.34, P=0.011). The FTSS limit value in predicting moderate cognitive impairment was set at 15 seconds by a sensitivity analysis (negative predictive value=86%).

Conclusion

We found a negative association of FTSS with global cognitive performance. Achieving FTSS in less than 15 seconds made unlikely the existence of a moderate cognitive impairment. FTSS could be used as a tool in primary care medicine to exclude moderate cognitive decline.

Key words

Five-Times-Sit-to-Standcognitionearly diagnosisolder adults

Abbreviations

FTSS

Five-Times-Sit-to-Stand test

SPMSQ

Short Portable Mental State Questionnaire

EPIDOS

EPIDémiologie de l’OStéoporose study

BMI

Body Mass Index

3MS

Modified Mini Mental State

MMSE

Mini Mental State Examination

Copyright information

© Serdi and Springer Verlag France 2011

Authors and Affiliations

  • Cédric Annweiler
    • 1
    • 6
  • A. -M. Schott
    • 2
  • G. Abellan Van Kan
    • 3
  • Y. Rolland
    • 3
  • H. Blain
    • 4
  • B. Fantino
    • 1
  • F. R. Herrmann
    • 5
  • O. Beauchet
    • 1
  1. 1.Department of Internal Medicine and Geriatrics, Angers University HospitalAngers University Memory Center; UPRES EA 2646, University of Angers, UNAMAngersFrance
  2. 2.Department IMER, Lyon University Hospital; EA 4129, RECIFUniversity of LyonLyonFrance
  3. 3.Department of GeriatricsToulouse University Hospital; INSERM U558, University of Toulouse IIIToulouseFrance
  4. 4.Department of Internal Medicine and GeriatricsMontpellier University HospitalMontpellierFrance
  5. 5.Department of Rehabilitation and GeriatricsGeneva University Hospitals; University of GenevaGenevaSwitzerland
  6. 6.Department of Internal Medicine and GeriatricsAngers University HospitalAngers Cedex 9France