The journal of nutrition, health & aging

, Volume 14, Issue 10, pp 823–827

Bioelectrical impedance vector analysis detects low body cell mass and dehydration in patients with Alzheimer’s disease

  • R. Buffa
  • R. M. Mereu
  • P. F. Putzu
  • G. Floris
  • Elisabetta Marini
JNHA: Clinical Neurosciences

DOI: 10.1007/s12603-010-0115-9

Cite this article as:
Buffa, R., Mereu, R.M., Putzu, P.F. et al. J Nutr Health Aging (2010) 14: 823. doi:10.1007/s12603-010-0115-9

Abstract

Objectives

This paper evaluates the nutritional status in patients with mild-moderate and severe Alzheimer’s disease (AD) by bioelectrical impedance vector analysis (BIVA).

Design

Cross-sectional study. Setting: Alzheimer Center, SS. Trinità Hospital, Cagliari, and “Monsignor Angioni” Nursing Home, Quartu Sant’Elena (Cagliari, Italy).

Participants

83 free-living patients with mild-moderate Alzheimer’s disease (29 men, 54 women), 9 institutionalized women in the severe stage; 468 age-matched controls (202 men, 266 women).

Measurements

Mini Nutritional Assessment (MNA), anthropometric (height, weight, BMI), bioelectrical (R, Xc) and biochemical variables (serum albumin) were assessed.

Results

Bioelectrical characteristics were significantly different in the patients with mild-moderate AD with respect to controls, indicating low body cell mass (men, T2= 12.8; women, T2=34.9; p<0.01). Women with severe AD showed low body cell mass and dehydration with respect to patients with mild-moderate AD (T2=17.1; p<0.01). The phase angle, R/H and Z/H were significantly correlated (p<0.05) with MNA (phase: r = 0.31; R/H: r =−0.37; Z/H: r =−0.37) and albumin (phase: r=0.47; R/H: r=−0.36; Z/H: r=−0.36).

Conclusion

Alzheimer’s disease is characterized by a tendency to malnutrition, present even in the mild-moderate stages, and a tendency to dehydration that appears in the severe stage. The BIVA technique is a promising tool for the screening and monitoring of nutrition and hydration status in Alzheimer’s disease.

Key words

Alzheimer’s diseaseBIVAnutritional statushydration status

Non-standard abbreviations

BIA

Bioelectrical Impedance Analysis

BIVA

Bioelectrical Impedance Vector Analysis

MNA

Mini Nutritional Assessment

CDR

Clinical Dementia Rating

NINCDS-ADRDA

National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer’s Disease and Related Disorders

MMSE

Mini Mental State Examination

R

Resistance

Xc

Reactance

Z

Impedance

Copyright information

© Serdi and Springer Verlag France 2010

Authors and Affiliations

  • R. Buffa
    • 1
  • R. M. Mereu
    • 2
  • P. F. Putzu
    • 2
  • G. Floris
    • 1
  • Elisabetta Marini
    • 1
    • 3
  1. 1.Department of Experimental Biology, Anthropological Science SectionUniversity of CagliariCagliariItaly
  2. 2.Geriatric DivisionSS Trinità HospitalCagliariItaly
  3. 3.Department of Experimental Biology, Anthropological Science SectionUniversity of CagliariMonserrato (Cagliari)Italy