Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: Findings from NHANES III
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Sarcopenia may be related to increases in reactive oxygen species formation and inflammation, both of which are associated with elevations in serum uric acid.
To test the hypothesis that a reduced skeletal muscle mass index, indicative of sarcopenia, is related to elevations in uric acid.
Cross-sectional analysis of nationally representative data.
Third National Health and Nutrition Examination Survey, 1988–1994.
7544 men and women 40 years of age and older who had uric acid, skeletal muscle mass, and select covariate information.
Skeletal muscle mass assessment was based on a previously published equation including height, BIA-resistance, gender, and age. Absolute skeletal muscle mass was calculated for all study population individuals and compared against the sex-specific mean for younger adults. Serum uric acid data were gathered from the NHANES laboratory file.
A logistic regression analysis revealed that elevations in serum uric acid are significantly related to sarcopenia status. For every unit (mg/dL) increase in uric acid, the odds ratio of manifesting a skeletal muscle mass index at least one standard deviation below the reference mean was 1.12. Participants in the highest grouping (>8 mg/dL) of serum uric acid concentration had 2.0 times the odds of manifesting sarcopenia compared to the lowest grouping (<6 mg/dL) (p<0.01) after adjusting for the additional covariates.
This study design was limited in its cross-sectional nature. Potential selection, measurement, and recall bias may have occurred, and methodology used to classify sarcopenia status based on skeletal muscle mass index is not validated.
This observation provides support for the theory that elevations in uric acid may lead to sarcopenia, although the proposed mechanism needs further experimental support.
- United Nations. Report of the Second World Assembly on Aging. Madrid, Spain: April 8–12, 2002.
- U.S. Census Bureau. International database. Table 094. Midyear population, by age and sex.
- Marzani B, Felzani G, Bellomo RG, Vecchiet J, Marzatico F. Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles. Exp Gerontol 2005;40:959–965.
- Beck J, Ferrucci L, Sun K, et al. Low serum selenium concentrations are associated with poor grip strength among older women living in the community. Biofactors 2007;29:37–44. CrossRef
- Howard C, Ferrucci L, Sun K, et al. Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol 2007;103:17–20. CrossRef
- Lindle RS, Metter EJ, Lynch NA, et al. Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr. J Appl Physiol 1997;83:1581–1587.
- Johnson RJ, Segal MS, Srinivas T, et al. Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol 2005;16:1909–1919. CrossRef
- Leyva F, Anker S, Swan JW, et al. Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. Eur Heart J 1997;18:858–865.
- Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 2007;120:442–447. CrossRef
- Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50:889–896. CrossRef
- Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 1988–1994. http://www.cdc.gov/nchs/about/major/nhanes/nh3data.htm
- World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series 894. Geneva, Switzerland: 2000.
- Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007;39:1423–1434. CrossRef
- SAS Institute Inc., SAS 9.1.3 Help and Documentation, Cary, NC: SAS Institute Inc., 2000–2004.
- Hollmann W, Struder HK, Tagarakis CV, King G. Physical activity and the elderly. Eur J Cardiovasc Prev Rehabil 2007;14:730–739. CrossRef
- Evans W. Functional and metabolic consequences of sarcopenia. J Nutr 1997;127:998S–1003S.
- Castaneda C, Janssen I. Ethnic comparisons of sarcopenia and obesity in diabetes. Ethn Dis 2005;15:664–670.
- Melzer K, Kayser B, Pichard C. Physical activity: the health benefits outweigh the risks. Curr Opin Clin Nutr Metab Care 2004;7:641–647. CrossRef
- Bunout D, de la Maza MP, Barrera G, Leiva L, Gattas V, Hirsch S. Assessment of sarcopenia: longitudinal versus cross sectional body composition data. Aging Clin Exp Res 2007;19:295–299.
- Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 2007;86:633–638.
- Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 2008;87:1562S–1566S.
- Petersen AM, Magkos F, Atherton P, et al. Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab 2007;293:E843–E848. CrossRef
- Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med 2001;137:231–243. CrossRef
- Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004;52:80–85. CrossRef
- Duan X, Ling F. Is uric acid itself a player or a bystander in the pathophysiology of chronic heart failure? Med Hypotheses 2008;70:578–581. CrossRef
- Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298–300.
- Martin C, Dubouchaud H, Mosoni L, et al. Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius. Aging Cell 2007;6:165–177. CrossRef
- Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 2006;17:1807–1819. CrossRef
- Robinson PA, Ardley HC. Ubiquitin-protein ligases. J Cell Sci 2004;117:5191–5194. CrossRef
- Attaix D, Ventadour S, Codran A, Bechet D, Taillandier D, Combaret L. The ubiquitinproteasome system and skeletal muscle wasting. Essays Biochem 2005;41:173–186. CrossRef
- Russell ST, Eley H, Tisdale MJ. Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II. Cell Signal 2007;19:1797–1806. CrossRef
- Li YP, Chen Y, Li AS, Reid MB. Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. Am J Physiol Cell Physiol 2003;285:C806–C812.
- Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007;293:C584–C596. CrossRef
- Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol 2007;102:2389–2397. CrossRef
- Moylan JS, Reid MB. Oxidative stress, chronic disease, and muscle wasting. Muscle Nerve 2007;35:411–429. CrossRef
- Langen RC, Schols AM, Kelders MC, Van Der Velden JL, Wouters EF, Janssen-Heininger YM. Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways. Am J Physiol Cell Physiol 2002;283:C714–C721.
- Patel J, McLeod LE, Vries RG, Flynn A, Wang X, Proud CG. Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem 2002;269:3076–3085. CrossRef
- Cirillo P, Sato W, Reungjui S, et al. Uric acid, the metabolic syndrome, and renal disease. J Am Soc Nephrol 2006;17:S165–S168. CrossRef
- Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005;67:1739–1742. CrossRef
- Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001;38:1101–1106. CrossRef
- Alper AB, Jr, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension 2005;45:34–38.
- Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005;16:3553–3562. CrossRef
- Waring WS, Webb DJ, Maxwell SR. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovasc Pharmacol 2001;38:365–371. CrossRef
- Kutzing MK, Firestein BL. Altered uric acid levels and disease states. J Pharmacol Exp Ther 2008;324:1–7. CrossRef
- Rentzos M, Nikolaou C, Anagnostouli M, et al. Serum uric acid and multiple sclerosis. Clin Neurol Neurosurg 2006;108:527–531. CrossRef
- Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 2000;89:465–471.
- Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: Findings from NHANES III
JNHA - The Journal of Nutrition, Health and Aging
Volume 13, Issue 3 , pp 177-182
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- Uric acid
- NHANES III
- reactive oxygen species
- Industry Sectors
- Author Affiliations
- 1. Department of Health, Human Performance, and Recreation, Baylor University, Center for Exercise, Nutrition, and Preventive Health Research, Waco, TX, 76798-7313, USA
- 2. Department of Statistics, Baylor University, Waco, TX, 76798-7313, USA
- 3. 3Central Texas Nephrology Associates, 2329 N 39th Street, Waco, TX, 76708, USA