European Orthopaedics and Traumatology

, Volume 2, Issue 1, pp 3–5

From proof to practice: innovations in total hip and total knee replacement—modern anticoagulation

Review Article

DOI: 10.1007/s12570-011-0064-8

Cite this article as:
Perka, C. Eur Orthop Traumatol (2011) 2: 3. doi:10.1007/s12570-011-0064-8



Venous thromboembolism (VTE) and pulmonary embolism (PE) can be life-threatening complications after orthopaedic surgery. Last-generation oral anticoagulants like dabigatran etexilate, rivaroxaban and apixaban have the potential to become a standard in the VTE and PE prophylaxis.


Study data about the long-term efficacy and safety of dabigatran etexilate with focus in orthopaedics surgery are given and discussed by Menno Huisman (Leiden, The Netherlands), Alberto Delgado-Martinez (Jaén, Spain) and Stefano Zanasi (Florence, Italy).


The study as well as the personal experience reflects the efficacy and safety of dabigatran etexilate in orthopaedic surgery in terms of prophylaxis of VTE and PE and perioperative bleeding.


Based on the actual data, the therapeutic efficacy of last-generation oral anticoagulants is not negatively influenced by their easy handling (oral administration, fixed dosage and no anticoagulation monitoring).


Apixaban Dabigatran etexilate Oral anticoagulants Orthopaedics Rivaroxaban Venous thromboembolism 

Copyright information

© EFORT 2011

Authors and Affiliations

  1. 1.Centre for Endoprosthetic and Reconstructive Joint Surgery Orthopaedic Department, CharitéUniversity Medicine BerlinBerlinGermany
  2. 2.Centre for Musculoskeletal Surgery Orthopaedic Department, CharitéUniversity Medicine Berlin, Free and Humboldt-University of BerlinBerlinGermany

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