, Volume 3, Issue 2, pp 145-168
Date: 21 Oct 2011

Innovative Clinical Trial Designs

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Abstract

Whereas the 20th-century health care system sometimes seemed to be inhospitable to and unmoved by experimental research, its inefficiency and unaffordability have led to reforms that foreshadow a new health care system. We point out certain opportunities and transformational needs for innovations in study design offered by the 21st-century health care system, and describe some innovative clinical trial designs and novel design methods to address these needs and challenges.

T.L. Lai supported in part by NIH grant 1 P30 CA124435-01 and NSF grant DMS 0805879.
P.W. Lavori supported in part by NIH grant R01 MH051481 and clinical and translational science award 1 UL1 RR025744.