Biophysical Reviews

, Volume 5, Issue 1, pp 29-39

First online:

SH3 domains: modules of protein–protein interactions

  • Natalya KurochkinaAffiliated withDepartment of Biophysics, The School of Theoretical Modeling Email author 
  • , Udayan GuhaAffiliated withMedical Oncology Branch, National Cancer Institute, National Institutes of Health

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Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.


Three-dimensional structure SH3 domain Cell signaling Src-family Myosin Protein conformation