Review

Biophysical Reviews

, Volume 5, Issue 1, pp 29-39

First online:

SH3 domains: modules of protein–protein interactions

  • Natalya KurochkinaAffiliated withDepartment of Biophysics, The School of Theoretical Modeling Email author 
  • , Udayan GuhaAffiliated withMedical Oncology Branch, National Cancer Institute, National Institutes of Health

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Abstract

Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.

Keywords

Three-dimensional structure SH3 domain Cell signaling Src-family Myosin Protein conformation