Review

Biophysical Reviews

, Volume 3, Issue 4, pp 171-184

First online:

Luminescent nanodiamonds for biomedical applications

  • Jana M. SayAffiliated withARC Centre of Excellence for Engineered Quantum Systems, Department of Physics and Astronomy, Macquarie UniversityDepartment of Chemistry and Biomolecular Sciences, Macquarie University
  • , Caryn van VredenAffiliated withSchool of Medical Sciences, Bosch Institute, Department of Pathology, The University of Sydney
  • , David J. ReillyAffiliated withARC Centre of Excellence for Engineered Quantum Systems, The School of Physics, The University of Sydney
  • , Louise J. BrownAffiliated withDepartment of Chemistry and Biomolecular Sciences, Macquarie University
  • , James R. RabeauAffiliated withARC Centre of Excellence for Engineered Quantum Systems, Department of Physics and Astronomy, Macquarie University Email author 
  • , Nicholas J. C. KingAffiliated withSchool of Medical Sciences, Bosch Institute, Department of Pathology, The University of Sydney Email author 

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Abstract

In recent years, nanodiamonds have emerged from primarily an industrial and mechanical applications base, to potentially underpinning sophisticated new technologies in biomedical and quantum science. Nanodiamonds are relatively inexpensive, biocompatible, easy to surface functionalise and optically stable. This combination of physical properties are ideally suited to biological applications, including intracellular labelling and tracking, extracellular drug delivery and adsorptive detection of bioactive molecules. Here we describe some of the methods and challenges for processing nanodiamond materials, detection schemes and some of the leading applications currently under investigation.

Keywords

Nanodiamond Nitrogen-vacancy centre Fluorescence Imaging Biofunctionalisation Drug delivery