Mycotoxin Research

, Volume 26, Issue 1, pp 31–46

Complex etiology and pathology of mycotoxic nephropathy in South African pigs

  • Stoycho D. Stoev
  • Stefan Denev
  • Mike F. Dutton
  • Patrick B. Njobeh
  • Joseph S. Mosonik
  • Paul A. Steenkamp
  • Iordan Petkov
Original Paper

DOI: 10.1007/s12550-009-0038-7

Cite this article as:
Stoev, S.D., Denev, S., Dutton, M.F. et al. Mycotox Res (2010) 26: 31. doi:10.1007/s12550-009-0038-7

Abstract

Spontaneous nephropathy in pigs seen in South Africa was found to have multi-mycotoxic etiology involving several mycotoxins such as ochratoxin A (OTA), penicillic acid (PA) and fumonisin B1 (FB1) in addition to a not yet identified mycotoxin. Contamination levels of OTA were comparatively low (67–75 μg/kg) in contrast to high contamination levels of FB1 (5,289–5,021 μg/kg) and PA (149–251 μg/kg). A heavy contamination with Gibberella fujikuroi var. moniliformis and Penicillium aurantiogriseum complex (mainly P. polonicum) was observed in the fed forages in contrast to the light contamination with Aspergillus ochraceus, P. verrucosum and P. citrinum. The pathomorphological picture of this nephropathy was found to differ from the classical description of mycotoxic porcine nephropathy as originally made in Scandinavia by the extensive vascular changes.

Keywords

Ochratoxin APenicillic acidCitrininFumonisin B1MycotoxinsMycotoxic nephropathyPigs

Abbreviations

AFs

Aflatoxins

BEN

Balkan endemic nephropathy

CIT

Citrinin

CA

Cyclopiazonic acid

DAS

Diacetoxyscirpenol

DON

Deoxynivalenol

ERY

Erythroskyrin

FB1

Fumonisin B1

FB2

Fumonisin B2

GLI

Gliotoxin

ISL

Islanditoxin

KA

Kojic acid

LUT

Luteoskyirin

MPN

Mycotoxic porcine nephropathy

MCN

Mycotoxic chicken nephropathy

MON

Moniliformin

MTT

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

OTA

Ochratoxin A

OTC

Ochratoxin C

OOS

Oosporein (isoosporin)

PenA

Penitrem A

PAT

Patulin

PA

Penicillic acid

ppb

μg/kg

T-2

T-2 toxin

UM

Unknown metabolite

XA

Xanthomegnin

ZEA

Zearalenone.

Copyright information

© Society for Mycotoxin Research and Springer 2009

Authors and Affiliations

  • Stoycho D. Stoev
    • 1
  • Stefan Denev
    • 2
  • Mike F. Dutton
    • 3
  • Patrick B. Njobeh
    • 3
  • Joseph S. Mosonik
    • 3
  • Paul A. Steenkamp
    • 4
  • Iordan Petkov
    • 5
  1. 1.Department of General and Clinical Pathology, Faculty of Veterinary MedicineTrakia UniversityStara ZagoraBulgaria
  2. 2.Department of Microbiology, Faculty of AgricultureTrakia UniversityStara ZagoraBulgaria
  3. 3.Food, Environment and Health Research Group, Faculty of Health ScienceUniversity of JohannesburgGautengSouth Africa
  4. 4.Council for Scientific and Industrial Research, BiosciencesModderfonteinSouth Africa
  5. 5.State Veterinary ServicePretoriaSouth Africa