Lifestyle Changes in Women at Genetic Risk of Breast Cancer: an Observational Study
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Lifestyle influences breast cancer risk. Women at increased familial risk may benefit from modifying behaviour, but it is not known to what extent they do so.
This study aims to measure changes that UK (Scottish) women make in response to increased familial risk of breast cancer and attitudes to a risk-reduction trial.
A questionnaire, completed by 140 “breast cancer family” clinic patients, generated data on habitual diet, alcohol consumption and exercise, changes made after learning of breast cancer risk and attitudes to possible further changes. Subgroups of patients were defined by criteria likely to influence changes in behaviour. Between-group differences were analysed by Fisher's exact test and overall correlations by linear regression.
Thirty-six subjects (26 %) reported no behavioural change but, overall, around 25 % of diet, exercise and alcohol items had been changed. Women perceiving their lifetime cancer risk to be high (>50 %) and those who were obese (BMI >25) had made significantly more changes than others. Younger women (<40 years) and those with daughters had made fewer changes. Almost all suggested elements of a risk-reduction trial were strongly supported.
Scottish women at increased risk of breast cancer have scope for protective changes in lifestyle and support a risk-reduction trial. The needs of younger women and of those with daughters should be addressed in its design.
- Haites N, Hodgson SV and the Scottish Office Working Group. Guidelines for the development of cancer genetics services. In: P J Morrison, SV Hodgson and NE Haites (eds) Familial breast and ovarian cancer: genetics, screening and management. Cambridge University Press 2002, pp 166-203.
- National Institute for Clinical Excellence (NICE). Familial breast cancer: clinical guideline no. 14. NHS London, 2004.
- King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science. 2003;302:643–6. CrossRef
- Trygvadottir L, Sigvaldason H, Olafsdottir GH, Johansson JG, Jonsson T, Tulinius H, Eyfjord JE. Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation-carriers, 1920–2000. J Natl Cancer Inst. 2006;98:116–22. CrossRef
- Evans DG, Shenton A, Woodward E, Lalloo F, Howell A, Maher ER. Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a clinical cancer genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family. BMC Cancer. 2008;8:155.
- Gramling R, Lash T, Rothman KJ, Cabral HJ, Silliman R, Roberts M, Stefanick ML, Harrigan R, Bertoia ML, Eaton CB. Family history of later-onset breast cancer, breast healthy behaviour and invasive breast cancer among postmenopausal women: a cohort study. Breast Cancer Res. 2010;12:R82. CrossRef
- Vachon CM, Cerhan JR, Vierkant RA, Sellers TA. Investigation of an interaction of alcohol intake and family history on breast cancer risk in the Minnesota Breast Cancer Family study. Cancer. 2001;92:240–8. CrossRef
- Carpenter CL, Ross RK, Paganini-Hill A, Bernstein L. Effect of family history, obesity and exercise on breast cancer risk among postmenopausal women. Int J Cancer. 2003;106:96–102. CrossRef
- Narod SA. Modifiers of risk in hereditary breast and ovarian cancer. Nature Rev Cancer. 2002;2:113–23. CrossRef
- Kushi LH, Byers T, Doyle C, Bandera EV et al., American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. (2006). http://caonline.americancancersoc.org/cgi/content/full/56/5/254.
- World Cancer Research Fund and American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington DC: AICR, 2007.
- Gonzales CA, Riboli E. Diet and cancer prevention: contributions from the European prospective investigation into cancer and nutrition (EPIC) study. Eur J Cancer. 2010;46:2555–62. CrossRef
- Willett WC. Fruits, vegetables and cancer prevention: turmoil in the produce section. J Natl Cancer Inst. 2010;102:510–1. CrossRef
- Pasani P, Berrino J, Fusconi E, Curtosi PFB. A European Case-Only Study (COS) on familial breast cancer. J Nutr. 2005;135:3040S–1S.
- Holmes MD, Pollack MN, Willett WC, Hankinson SE. Dietary correlates of plasma insulin-like growth factor1 and insulin-like growth factor protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 2002;11:852–61.
- Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV. Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr. 2010;91:1294–302. CrossRef
- Ambrosone CB, Marshall JR, Vena JE, Laughlin R, Graham S, Hemoto T, Freudenheim JL. Interaction of family history of breast cancer and dietary anti-oxidants with breast cancer risk. Cancer Causes Control. 1995;6:407–15. CrossRef
- Cade JE, Burley VJ, Greenwood C, the UK Women's Cohort Study Group. Dietary fibre and risk of breast cancer in the UK women's cohort study. Int J Epidemiol. 2007;36:431–8. CrossRef
- Larsson SC, Akesson A, Bergkvist L, Wolk A. Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. Am J Clin Nutr. 2010;91:1268–72. CrossRef
- Cui Y, Rohan E. Vitamin D, calcium and breast cancer risk: a review. Cancer Epidemiol Biomarkers Prev. 2006;15:1427–37. CrossRef
- Chappuis PO and Foulkes WD. Management of BRCA1/2 mutation carriers. Ch. 15. In: PJ Morrison, SV Hodgson and NE Haites, (eds) Familial Breast and Ovarian Cancer: Genetics, Screening and Management. Cambridge University Press 2002. Pp 237-274
- Juilian-Reynier C, Eisenger F, Chabal F, Aurran Y, et al. Cancer genetics clinics; target populations and consultees' expectations. Eur J Cancer. 1996;32A:398–403. CrossRef
- McLeish L. Demands and needs of women attending 2 Scottish family history breast cancer clinics. MSc thesis, University of Manchester. 2003.
- Report of Working Party of the Chief Medical Officer for Scotland. “Scotland's Health: a challenge to us all. The Scottish diet”. The Scottish Office, 2006. www.healthscotland.com/documents/1181.aspx.
- Gibson RS. Principles of nutritional assessment. Oxford University Press 2005.
- Kretsch MJ, Fong AK, Green MW. Behavioral and body size correlates of energy intake underreporting by obese and normal-weight women. J Am Diet Assoc. 1999;99:300–6. CrossRef
- Evans DGR, Burnell LD, Hopwood P, Howell A. Perception of risk in women with a family history of breast cancer. Br J Cancer. 1993;67:612–4. CrossRef
- Croyle RT, Lerman C. Risk Communication in genetic testing for cancer susceptibility. J Natl Cancer Inst Monogr. 1999;25:59–66. CrossRef
- Watson M, Lloyd S, Davidson J, Meyer L, Eeles R, Ebbs S, Murday V. The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancer. Br J Cancer. 1999;79:868–74. CrossRef
- Cull A, Anderson E, Campbell J, Mackay J, Smyth E, Steel M. The impact of genetic counselling about breast cancer risk on women's risk perceptions and levels of distress. Br J Cancer. 1999;79:501–8. CrossRef
- Hopwood P, Shenton A, Lalloo F, Evans DG, Howell A. Risk perception and cancer worry: an exploratory study of the impact of genetic risk counselling in women with a family history of breast cancer. J Med Genet. 2001;38:139–42. CrossRef
- Ziegler RG, Hoover RN, Pike MC, Hildsheim A, et al. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst. 1993;85:1819–27. CrossRef
- Tudor Hart J. The inverse care law. Lancet. 1971;297:405–12. CrossRef
- Begum P, Richardson CE, Carmichael AR. Obesity in post-menopausal women with a family history of breast cancer: prevalence and risk awareness. Int Semin Oncol. 2009;6:1.
- Spector D, Mishel M, Skinner CS, Deroo LA, van Riper M, Sandler DP. Breast cancer risk perception and lifestyle behaviors among white and black women with a family history. Cancer Nurs. 2009;32:299–308. CrossRef
- McEligot AJ, Moutappa M, Ziogas A, Anton-Culver H. Diet and predictors of dietary intakes in women with family history of breast and/or ovarian cancer. Cancer Epidemiol. 2009;33:419–23. CrossRef
- Quach J, Porter K, Leventhal H, Kelly KM. Health behaviors among Ashkenazi Jewish individuals receiving counselling for BRCA1 and BRCA2 mutations. Fam Cancer. 2009;8:241–50. CrossRef
- Ochoa EM, Gomez-Acebo I, Rodriguez-Cundin P, Navarro-Cordoba M, Llorca J, Diersson-Sotos T. Relationship between family history of breast cancer and health-related behaviour. Behav Med. 2010;36:123–9. CrossRef
- Spector D, DeRoo LA, Sandler DP. Lifestyle behaviors in black and white women with a family history of breast cancer. Prev Med. 2011;52:394–7. CrossRef
- DiGianni LM, Rue M, Emmons K, Garber JE. Complementary medicine use before and one year following genetic testing for BRCA1/2 mutations. Cancer Epidemiol Biomarkers Prev. 2006;15:70–5. CrossRef
- Myers CD, Jacobsen PB, Huang Y, Frost MH, Patten CA, Cerhan JR, Sellers TA. Familial and perceived risk of breast cancer in relation to use of complementary medicine. Cancer Epidemiol Biomarkers Prev. 2008;17:1727–534. CrossRef
- Cole-Lewis H, Kershaw T. Text messaging as a tool for behaviour change in disease prevention and management. Epidemiol Rev. 2010;32:56–9. CrossRef
- Young RJ, Taylor J, Friede T, Hollis S, et al. Pro-active call center treatment support (PACCTS) to improve glucose control in type 2 diabetes: a randomised controlled trial. Diabetes Care. 2005;28:278–82. CrossRef
- Lifestyle Changes in Women at Genetic Risk of Breast Cancer: an Observational Study
International Journal of Behavioral Medicine
Volume 20, Issue 4 , pp 514-521
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Breast cancer
- Behavioural intervention
- Author Affiliations
- 1. Department of Clinical Genetics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
- 2. Tayside Familial Breast/Ovarian Cancer Service, Ninewells Hospital, Dundee, DD1 9SY, UK
- 3. Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
- 4. Nightingale and Genesis Prevention Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK
- 5. Medical School, University of St Andrews North Haugh, St Andrews, KY16 9TF, UK