Sex-discordant twins despite single embryo transfer: a report of two cases
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
We report two extremely rare cases in which the patients delivered male and female infants that were dizygotic twins (DZT) despite single embryo transfer. Case 1: The patient was a 35-year-old woman with a 9-year history of unexplained infertility. In an oocyte retrieval cycle, one blastocyst was transferred; at 26 weeks of gestation, she delivered a 704-g female infant and a 420-g male infant by cesarean section. Because both infants were of extremely low birth weight, they were placed in the neonatal intensive care unit. Congenital anomalies were not found in either infant. Case 2: The patient was a 30-year-old woman with a 1-year history of infertility. Hysterosalpingogram revealed bilateral tubal occlusion. In a frozen/thawed cycle one blastocyst was transferred during her natural ovulation cycle. She achieved a pregnancy and delivered a 2,877-g female infant and a 2,544-g male infant at 36 weeks of gestation by cesarean section. The female infant was diagnosed with a neural tube defect. No congenital anomalies were detected in the male infant. We hypothesize that the DZTs might have been the result of concurrent embryo transfer and natural ovulation and intercourse.
Supplementary Material (0)
- Bergh C. Single embryo transfer: a mini-review. Hum Reprod. 2005;20:323–7. CrossRef
- Japan Society of Obstetrics and Gynecology. Notice of avoiding multiple pregnancies in ART. Jpn J Obstet Gynecol. 2008; 60: 1159 (in Japanese).
- Sugawara N, Komaba R, Maeda M, Araki Y. The study for reducing multiple pregnancy rate by elective single embryo transfer. J Fert Imp (Tokyo). 2008;25:157–61 (in Japanese).
- Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation. Hum Reprod. 2001;16:1264–9. CrossRef
- Alikani M, Cekleniak NA, Walters E, Cohen J. Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases. Hum Reprod. 2003;18:1937–43. CrossRef
- Edwards RG, Mettler L, Walters DE. Identical twins and in vitro fertilization. J In Vitro Fert Embryo Transf. 1986;3:114–7. CrossRef
- Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteghem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med. 2006;354:1139–46. CrossRef
- Chow JS, Benson CB, Racowsky C, Doubilet PM, Ginsburg E. Frequency of a monochorionic pair in multiple gestations: relationship to mode of conception. J Ultrasound Med. 2001;20:757–60. quiz 761.
- Schoolcraft WB, Gardner DK, Lane M, Schlenker T, Hamilton F, Meldrum DR. Blastocyst culture and transfer: analysis of results and parameters affecting outcome in two in vitro fertilization programs. Fertil Steril. 1999;7:604–9. CrossRef
- Behr B, Fisch JD, Racowsky C, Miller K, Pool TB, Milki AA. Blastocyst-ET and monozygotic twinning. J Assist Reprod Genet. 2000;17:349–51. CrossRef
- Peramo B, Ricciarelli E, Cuadros-Fernandez JM, Huguet E, Hernandez ER. Blastocyst transfer and monozygotic twinning. Fertil Steril. 1999;72:1116–7. CrossRef
- Jain JK, Boostanfar R, Slater CC, Francis MM, Paulson RJ. Monozygotic twins and triplets in association with blastocyst transfer. J Assist Reprod Genet. 2004;21:103–7. CrossRef
- da Costa AL, Abdelmassih S, de Oliveira FG, Abdelmassih V, Abdelmassih R, Nagy ZP, et al. Monozygotic twins and transfer at the blastocyst stage after ICSI. Hum Reprod. 2001;16:333–6. CrossRef
- Milki AA, Jun SH, Hinckley MD, Behr B, Giudice LC, Westphal LM. Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertil Steril. 2003;79:503–6. CrossRef
- Papanikolaou EG, D’haeseleer E, Verheyen G, van de Velde H, Camus M, van Steirteghem A, et al. Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study. Hum Reprod. 2005;20:3198–203. CrossRef
- Sugawara N, Maeda M, Komaba R, Araki Y. The study of clinical assessment for elective single embryo transfer using new embryo’s Score. J Fert Imp (Tokyo). 2009;26:167–71 (in Japanese).
- Sugawara N, Komaba R, Maeda M, Araki Y. Comparison of implantation, pregnancy and miscarriage rates by between transfer of 2 or 3 embryos at the early cleaved stage. J Fert Imp (Tokyo). 2006;23:234–8 (in Japanese).
- Sadler TW (Yasuda M, Sawano J translators). Langman’s medical embryology, Tokyo: Medical Sciences International; 8 revised 8 edition; 2001, pp 141–148.
- Zech NH, Wisser J, Natalucci G, Riegel M, Baumer A, Schinzel A. Monochorionic-diamniotic twins discordant in gender from a naturally conceived pregnancy through postzygotic sex chromosome loss in a 47, XXY zygote. Prenat Diagn. 2008;28:759–63. CrossRef
- Jkemans Ei, Lintsen MJ, Hunault AM, Bouwmans CC, Hakkaart CA, Braat L, et al. Pregnancy chances on an IVF/ICSI waiting list: a national prospective cohort study. Hum Reprod. 2008;23:1627–32. CrossRef
- Hall JG. Twinning. Lancet. 2003;362:735–43. CrossRef
- Souter VL, Kapur RP, Nyholt DR, Skogerboe K, Myerson D, Ton CC, et al. A report of dizygous monochorionic twins. N Engl J Med. 2003;349:154–8. CrossRef
- Mains L, Ryan G, Sparks A, Van Voorhis B. Sextuplets: an unusual complication of single embryo transfer. Fertil Steril. 2009;91:932.e1–2. CrossRef
About this Article
- Sex-discordant twins despite single embryo transfer: a report of two cases
Reproductive Medicine and Biology
Volume 9, Issue 3 , pp 169-172
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Dizygotic twin (DZT)
- Monozygotic twin (MZT)
- Multiple gestation
- Single embryo transfer
- Author Affiliations
- 1. Iwaki Women’s Clinic, 3-2 Okishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan
- 2. Fukuchi Ladies’ Clinic, 2-17-4 Kashimamachi, Hitachi, Ibaraki, 317-0071, Japan
- 3. The Institute for ARMT, 909-21 Ishii, Fujimi, Maebashi, Gunma, 371-0105, Japan