World Journal of Pediatrics

, Volume 7, Issue 3, pp 232–239

Follow-up results of children with melamine induced urolithiasis: a prospective observational cohort study

  • Jian Gao
  • Hong Xu
  • Xin-Yu Kuang
  • Wen-Yan Huang
  • Nai-Qing Zhao
  • Jia Rao
  • Qiang-Ying Qian
  • Xian-Ying Cheng
  • Zhi-Min Feng
  • Jing Xu
  • Xin Zhang
  • Xiang Wang
Original Article

DOI: 10.1007/s12519-011-0293-5

Cite this article as:
Gao, J., Xu, H., Kuang, XY. et al. World J Pediatr (2011) 7: 232. doi:10.1007/s12519-011-0293-5

Abstract

Background

Melamine-contaminated milk powder was the cause of the 2008 outbreak of urolithiasis in young children and infants in China, but the prognosis of these children remains unknown. We hypothesized that urolithiasis induced by melamine-contaminated milk powder may be associated with secondary renal injury.

Methods

A total of 8335 children (≤6 years old) with a history of consuming melamine-contaminated milk powder were screened. Urine analysis and urinary system ultrasonography were performed. For children with urolithiasis, the basic information and the results of examination were recorded, and effective therapy was given. They were followed up for 6 months after the original diagnosis, and urinary microprotein profiles were measured.

Results

Of the 8335 children, 105 (1.26%) were diagnosed with melamine-contaminated milk powder-associated urolithiasis. The size of the stone was correlated with the duration of exposure to melamine. Six months later, 69.8% (67) of the children with urolithiasis passed stones (follow-up rate: 91.4%). Of the 67 children, 28 passed stones within 2 months. The higher possibility of passing a stone was correlated with the smaller diameter of the stone (P<0.001). The detection rate of abnormal urinary microprotein excretion (microalbumin, immunoglobulin G, and N-acetyl-β-D-glucosidase) was 52.4% in children with persistent stones and 38.2% in those who passed their stones. The detection rate was lower in children who passed stones within 2 months (31.8%) than in those who passed stones in 2 to 6 months (50.0%). The levels of microalbumin/creatinine and immunoglobulin G/creatinine were significantly higher in children with persistent stones than in those who passed their stones.

Conclusions

Early passage of a stone may reduce the renal injury induced by melamine-contaminated milk powder-associated urolithiasis.

Key words

children follow up melamine renal injury urolithiasis 

Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Jian Gao
    • 1
  • Hong Xu
    • 1
  • Xin-Yu Kuang
    • 1
  • Wen-Yan Huang
    • 1
  • Nai-Qing Zhao
    • 2
  • Jia Rao
    • 1
  • Qiang-Ying Qian
    • 1
  • Xian-Ying Cheng
    • 1
  • Zhi-Min Feng
    • 1
  • Jing Xu
    • 1
  • Xin Zhang
    • 1
  • Xiang Wang
    • 1
  1. 1.Department of NephrologyChildren’s Hospital of Fudan UniversityShanghaiChina
  2. 2.Department of Biostatistics and Social Medicines, School of Public HealthFudan UniversityShanghaiChina