Maternal obesity associated with inflammation in their children
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This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI).
The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2–123).
These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
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- Maternal obesity associated with inflammation in their children
World Journal of Pediatrics
Volume 8, Issue 1 , pp 76-79
- Cover Date
- Print ISSN
- Online ISSN
- SP Children’s Hospital, Zhejiang University School of Medicine
- Additional Links
- hs-C-reactive protein
- maternal obesity
- Author Affiliations
- 1. The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- 2. UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
- 4. Department of Pediatrics, Division of Gastroenterology and Nutrition, UMDNJ-RWJMS, 89 French Street, 2nd Floor, New Brunswick, NJ, 08901, USA
- 3. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA