Diabetologia

, Volume 45, Issue 1, pp 42–48

White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men

Authors

  • N. Nakanishi
    • Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
  • H. Yoshida
    • Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
  • Y. Matsuo
    • Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
  • K. Suzuki
    • Japan Labour and Welfare Association, Tokyo, Japan
  • K. Tatara
    • Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Article

DOI: 10.1007/s125-002-8243-1

Cite this article as:
Nakanishi, N., Yoshida, H., Matsuo, Y. et al. Diabetologia (2002) 45: 42. doi:10.1007/s125-002-8243-1

Abstract.

Aims/hypothesis:

To investigate the association between white blood-cell (WBC) count and the development of diabetes, independent of cigarette smoking.

Methods:

We examined 2953 Japanese men who were office workers and between 35 and 59 years of age and who did not have impaired fasting glucose (IFG) (a fasting glucose concentration of 6.1–6.9 mmol/l), Type II (non-insulin-dependent) diabetes mellitus (a fasting glucose concentration of ≥ 7.0 mmol/l or more or receipt of hypoglycaemic medication), medication for hypertension, and a history of cardiovascular disease. Fasting glucose concentrations were measured at annual health examinations from May 1994 through May 2000.

Results:

After controlling for potential predictors of diabetes, the relative risk for IFG or Type II diabetes mellitus compared with a WBC count of less than 5.3 · 109 cells/l was 1.2 (95 %-CI, 0.6–2.3), 1.6 (CI, 0.8–3.1), and 2.5 (CI, 1.2–5.1) among non-smokers (p for trend = 0.009): and 1.0 (CI, 0.4–2.5), 2.3 (CI, 1.0–5.1), and 3.1 (CI, 1.4–7.1) among ex-smokers (p for trend = 0.001) with WBC counts of 5.3–6.1, 6.2–7.2, and 7.3 · 109 cells/l or more, respectively. Among current smokers, the respective multivariate-adjusted relative risks for IFG or Type II diabetes mellitus were 1.1 (CI, 0.6–2.1), 1.4 (CI, 0.8–2.4), and 1.2 (CI, 0.7–2.1) (p for trend = 0.460).

Conclusion/hypothesis:

Although the selection of a rigorously normoglycaemic cohort might have had an influence on these observations, higher WBC counts seem to predict the development of IFG or Type II diabetes mellitus, primarily in non-smokers. [Diabetologia (2002) 45: 42–48]

Keywords Impaired fasting glucoseType II (non-insulin-dependent) diabetes mellitusincidencewhite blood-cell countcigarette smokinglongitudinal studyJapanese men.
Download to read the full article text

Copyright information

© Springer-Verlag Berlin Heidelberg 2002