Molecular MRI of atherosclerotic plaque with targeted contrast agents
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- Sosnovik, D.E. & Caravan, P. curr cardiovasc imaging rep (2009) 2: 87. doi:10.1007/s12410-009-0012-y
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Molecular MRI of atherosclerosis involves the use of novel contrast agents to image cellular and molecular processes within atherosclerotic plaque. Agents to image plaque lipid content, inflammation, angiogenesis, and thrombosis have been developed and studied extensively in animal models of atherosclerosis and vascular injury. Selected agents have also been studied in humans, with highly promising initial results. In this brief review, recent advances as well as opportunities and challenges in the field are discussed.