Journal of Nuclear Cardiology

, Volume 21, Issue 6, pp 1112–1128

Molecular imaging of plaque vulnerability

CME Article REVIEW ARTICLE

DOI: 10.1007/s12350-014-9959-4

Cite this article as:
Tavakoli, S., Vashist, A. & Sadeghi, M.M. J. Nucl. Cardiol. (2014) 21: 1112. doi:10.1007/s12350-014-9959-4

Abstract

Over the past decade, significant progress has been made in the development of novel imaging strategies focusing on the biology of the vessel wall for identification of vulnerable plaques. While the majority of these studies are still in the pre-clinical stage, few techniques (e.g., 18F-FDG and 18F-NaF PET imaging) have already been evaluated in clinical studies with promising results. Here, we will briefly review the pathobiology of atherosclerosis and discuss molecular imaging strategies that have been developed to target these events, with an emphasis on mechanisms that are associated with atherosclerotic plaque vulnerability.

Keywords

Atherosclerosis molecular imaging inflammation angiogenesis apoptosis 

Copyright information

© American Society of Nuclear Cardiology 2014

Authors and Affiliations

  • Sina Tavakoli
    • 1
  • Aseem Vashist
    • 2
    • 4
  • Mehran M. Sadeghi
    • 3
    • 4
  1. 1.Department of RadiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Section of CardiologyUniversity of Connecticut School of MedicineFarmingtonUSA
  3. 3.Section of Cardiovascular Medicine and Cardiovascular Research CenterYale University School of MedicineNew HavenUSA
  4. 4.VA Connecticut Healthcare SystemWest HavenUSA

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