Journal of Nuclear Cardiology

, Volume 21, Issue 3, pp 570–577

Differential effects of variation in athletes training on myocardial morphophysiological adaptation in men: Focus on 123I-MIBG assessed myocardial sympathetic activity

  • Douglas Pinheiro Miranda
  • Marcelo José dos Santos
  • Vera Maria Cury Salemi
  • Edmundo Pereira Caparelli de Oliveira
  • Hein J. Verberne
  • Euclides Timóteo da Rocha
Original Article

DOI: 10.1007/s12350-014-9876-6

Cite this article as:
Miranda, D.P., dos Santos, M.J., Salemi, V.M.C. et al. J. Nucl. Cardiol. (2014) 21: 570. doi:10.1007/s12350-014-9876-6

Abstract

Purpose

High intensity systematic physical training leads to myocardial morphophysiological adaptations. The goal of this study was to investigate if differences in training were correlated with differences in cardiac sympathetic activity.

Methods

58 males (19-47 years), were divided into three groups: strength group (SG), (20 bodybuilders), endurance group (EG), (20 endurance athletes), and a control group (CG) comprising 18 healthy non-athletes. Cardiac sympathetic innervation was assessed by planar myocardial 123I-metaiodobenzylguanidine scintigraphy using the early and late heart to mediastinal (H/M) ratio, and washout rate (WR).

Results

Left ventricular mass index was significantly higher both in SG (P < .001) and EG (P = .001) compared to CG without a statistical significant difference between SG and EG (P = .417). The relative wall thickness was significantly higher in SG compared to CG (P < .001). Both left ventricular ejection fraction and the peak filling rate showed no significant difference between the groups. Resting heart rate was significantly lower in EG compared to CG (P = .006) and SG (P = .002). The late H/M ratio in CG was significantly higher compared to the late H/M for SG (P = .003) and EG (P = .004). However, WR showed no difference between the groups. There was no significant correlation between the parameters of myocardial sympathetic innervation and parameters of left ventricular function.

Conclusions

Strength training resulted in a significant increase in cardiac dimensions. Both strength and endurance training seem to cause a reduction in myocardial sympathetic drive. However, myocardial morphological and functional adaptations to training were not correlated with myocardial sympathetic activity.

Keywords

Athletes evaluation heart sympathetic activity endurance strength 

Copyright information

© American Society of Nuclear Cardiology 2014

Authors and Affiliations

  • Douglas Pinheiro Miranda
    • 1
    • 2
  • Marcelo José dos Santos
    • 3
  • Vera Maria Cury Salemi
    • 4
  • Edmundo Pereira Caparelli de Oliveira
    • 3
  • Hein J. Verberne
    • 5
  • Euclides Timóteo da Rocha
    • 3
  1. 1.Post Graduation Program in Research and Development - Medical Biotechnology, Faculdade de Medicina de BotucatuUniversidade Estadual PaulistaBotucatuBrazil
  2. 2.Department of Physical EducationCentro Universitário da Fundação Educacional de BarretosBarretosBrazil
  3. 3.Department of Nuclear Medicine, Pios XII FoundationBarretos Cancer HospitalBarretosBrazil
  4. 4.The Heart Institute (Incor)Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão PauloBrazil
  5. 5.Department of Nuclear MedicineAcademic Medical Center, University of AmsterdamAmsterdamThe Netherlands

Personalised recommendations