Journal of Nuclear Cardiology

, Volume 19, Issue 4, pp 787–795

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

  • Yuka Otaki
  • Reza Arsanjani
  • Heidi Gransar
  • Victor Y. Cheng
  • Damini Dey
  • Troy Labounty
  • Fay Y. Lin
  • Stephan Achenbach
  • Mouaz Al-Mallah
  • Matthew J. Budoff
  • Filippo Cademartiri
  • Tracy Q. Callister
  • Hyuk-Jae Chang
  • Kavitha Chinnaiyan
  • Benjamin J. W. Chow
  • Augustin Delago
  • Martin Hadamitzky
  • Joerg Hausleiter
  • Philipp Kaufmann
  • Erica Maffei
  • Gilbert Raff
  • Leslee J. Shaw
  • Todd C. Villines
  • Allison Dunning
  • Ricardo C. Cury
  • Gudrun Feuchtner
  • Yong-Jin Kim
  • Jonathon Leipsic
  • Daniel S. Berman
  • James K. Min
Review Article

DOI: 10.1007/s12350-012-9582-1

Cite this article as:
Otaki, Y., Arsanjani, R., Gransar, H. et al. J. Nucl. Cardiol. (2012) 19: 787. doi:10.1007/s12350-012-9582-1

Abstract

Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

Keywords

Prognosiscoronary artery diseasecoronary CT angiography

Copyright information

© American Society of Nuclear Cardiology 2012

Authors and Affiliations

  • Yuka Otaki
    • 1
  • Reza Arsanjani
    • 1
  • Heidi Gransar
    • 1
  • Victor Y. Cheng
    • 1
    • 2
  • Damini Dey
    • 1
    • 2
    • 3
  • Troy Labounty
    • 1
  • Fay Y. Lin
    • 4
  • Stephan Achenbach
    • 6
  • Mouaz Al-Mallah
    • 7
  • Matthew J. Budoff
    • 8
  • Filippo Cademartiri
    • 9
    • 10
  • Tracy Q. Callister
    • 11
  • Hyuk-Jae Chang
    • 12
  • Kavitha Chinnaiyan
    • 13
  • Benjamin J. W. Chow
    • 14
  • Augustin Delago
    • 15
  • Martin Hadamitzky
    • 16
  • Joerg Hausleiter
    • 16
  • Philipp Kaufmann
    • 17
  • Erica Maffei
    • 9
    • 10
  • Gilbert Raff
    • 13
  • Leslee J. Shaw
    • 18
  • Todd C. Villines
    • 19
  • Allison Dunning
    • 5
  • Ricardo C. Cury
    • 20
  • Gudrun Feuchtner
    • 21
  • Yong-Jin Kim
    • 22
  • Jonathon Leipsic
    • 23
  • Daniel S. Berman
    • 1
    • 2
  • James K. Min
    • 1
    • 2
    • 24
  1. 1.Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Department of Medicine, David Geffen School of MedicineUniversity of California, Los AngelesLos AngelesUSA
  3. 3.Department of Biomedical Sciences and Biomedical Imaging Research InstituteCedars-Sinai Medical CenterLos AngelesUSA
  4. 4.Department of MedicineWeill Cornell Medical College and the New York Presbyterian HospitalNew YorkUSA
  5. 5.Department of Public HealthWeill Cornell Medical College and the New York Presbyterian HospitalNew YorkUSA
  6. 6.Department of MedicineUniversity of ErlangenErlangenGermany
  7. 7.Department of Medicine, Henry Ford HospitalWayne State UniversityDetroitUSA
  8. 8.Department of MedicineHarbor UCLA Medical CenterLos AngelesUSA
  9. 9.CardioVascular Imaging UnitGiovanni XXIII HospitalMonastierItaly
  10. 10.Department of RadiologyErasmus Medical CenterRotterdamThe Netherlands
  11. 11.Tennessee Heart and Vascular InstituteHendersonvilleUSA
  12. 12.Division of CardiologySeverance Cardiovascular HospitalSeoulSouth Korea
  13. 13.William Beaumont HospitalRoyal OakUSA
  14. 14.Department of Medicine and RadiologyUniversity of OttawaOttawaCanada
  15. 15.Capitol Cardiology AssociatesAlbanyUSA
  16. 16.Division of CardiologyDeutsches Herzzentrum MunchenMunichGermany
  17. 17.University HospitalZurichSwitzerland
  18. 18.Department of MedicineEmory University School of MedicineAtlantaUSA
  19. 19.Department of MedicineWalter Reed Medical CenterWashingtonUSA
  20. 20.Baptist Cardiac and Vascular InstituteMiamiUSA
  21. 21.Department of RadiologyMedical University of InnsbruckInnsbruckAustria
  22. 22.Seoul National University HospitalSeoulSouth Korea
  23. 23.Department of Medicine and RadiologyUniversity of British ColumbiaVancouverCanada
  24. 24.Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Heart InstituteCedars-Sinai Medical CenterLos AngelesUSA