Journal of Nuclear Cardiology

, Volume 19, Issue 4, pp 787–795

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Authors

  • Yuka Otaki
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
  • Reza Arsanjani
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
  • Heidi Gransar
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
  • Victor Y. Cheng
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
    • Department of Medicine, David Geffen School of MedicineUniversity of California, Los Angeles
  • Damini Dey
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
    • Department of Medicine, David Geffen School of MedicineUniversity of California, Los Angeles
    • Department of Biomedical Sciences and Biomedical Imaging Research InstituteCedars-Sinai Medical Center
  • Troy Labounty
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
  • Fay Y. Lin
    • Department of MedicineWeill Cornell Medical College and the New York Presbyterian Hospital
  • Stephan Achenbach
    • Department of MedicineUniversity of Erlangen
  • Mouaz Al-Mallah
    • Department of Medicine, Henry Ford HospitalWayne State University
  • Matthew J. Budoff
    • Department of MedicineHarbor UCLA Medical Center
  • Filippo Cademartiri
    • CardioVascular Imaging UnitGiovanni XXIII Hospital
    • Department of RadiologyErasmus Medical Center
  • Tracy Q. Callister
    • Tennessee Heart and Vascular Institute
  • Hyuk-Jae Chang
    • Division of CardiologySeverance Cardiovascular Hospital
  • Kavitha Chinnaiyan
    • William Beaumont Hospital
  • Benjamin J. W. Chow
    • Department of Medicine and RadiologyUniversity of Ottawa
  • Augustin Delago
    • Capitol Cardiology Associates
  • Martin Hadamitzky
    • Division of CardiologyDeutsches Herzzentrum Munchen
  • Joerg Hausleiter
    • Division of CardiologyDeutsches Herzzentrum Munchen
  • Philipp Kaufmann
    • University Hospital
  • Erica Maffei
    • CardioVascular Imaging UnitGiovanni XXIII Hospital
    • Department of RadiologyErasmus Medical Center
  • Gilbert Raff
    • William Beaumont Hospital
  • Leslee J. Shaw
    • Department of MedicineEmory University School of Medicine
  • Todd C. Villines
    • Department of MedicineWalter Reed Medical Center
  • Allison Dunning
    • Department of Public HealthWeill Cornell Medical College and the New York Presbyterian Hospital
  • Ricardo C. Cury
    • Baptist Cardiac and Vascular Institute
  • Gudrun Feuchtner
    • Department of RadiologyMedical University of Innsbruck
  • Yong-Jin Kim
    • Seoul National University Hospital
  • Jonathon Leipsic
    • Department of Medicine and RadiologyUniversity of British Columbia
  • Daniel S. Berman
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
    • Department of Medicine, David Geffen School of MedicineUniversity of California, Los Angeles
    • Departments of Imaging and Medicine, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
    • Department of Medicine, David Geffen School of MedicineUniversity of California, Los Angeles
    • Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Heart InstituteCedars-Sinai Medical Center
Review Article

DOI: 10.1007/s12350-012-9582-1

Cite this article as:
Otaki, Y., Arsanjani, R., Gransar, H. et al. J. Nucl. Cardiol. (2012) 19: 787. doi:10.1007/s12350-012-9582-1

Abstract

Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

Keywords

Prognosiscoronary artery diseasecoronary CT angiography

Copyright information

© American Society of Nuclear Cardiology 2012