, Volume 18, Issue 4, pp 580-587
Date: 03 Jun 2011

The future of SPECT MPI: Time and dose reduction

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Myocardial perfusion imaging (MPI) is the noninvasive method most commonly employed and used for the longest time for the evaluation of suspected and known coronary artery disease (CAD). MPI became possible due to the introduction of the Anger gamma camera in 1957 and the establishment of Thallium-201’s suitability for visualization of myocardial perfusion in 1973. Landmarks leading to the current applications of MPI include the transition from planar to SPECT imaging in 1976, the change from single- to dual-head gamma cameras, the introduction of coronary vasodilators for stress, the development of Tc-99m-based tracers in 1990s, the introduction of gating algorithms, the use of attenuation correction, and most recently the development of hybrid systems (SPECT/CT) and solid state detectors.

During this almost 50-year journey of nuclear cardiology, other noninvasive methods for similar indications became available: positron emission tomography (PET), stress echocardiography,