Journal of Nuclear Cardiology

, Volume 18, Issue 4, pp 685–694

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony


    • Department of Radiology and Imaging SciencesEmory University School of Medicine
  • Ernest V. Garcia
    • Department of Radiology and Imaging SciencesEmory University School of Medicine
  • Jeroen J. Bax
    • Department of CardiologyLeiden University Medical Center
  • Ami E. Iskandrian
    • Division of CardiologyUniversity of Alabama at Birmingham
  • Salvador Borges-Neto
    • Department of RadiologyDuke University Medical Center
  • Prem Soman
    • Cardiovascular InstituteUniversity of Pittsburgh Medical Center
Major Achievements in Nuclear Cardiology

DOI: 10.1007/s12350-011-9392-x

Cite this article as:
Chen, J., Garcia, E.V., Bax, J.J. et al. J. Nucl. Cardiol. (2011) 18: 685. doi:10.1007/s12350-011-9392-x


Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or implantable cardioverter defibrillator therapy and in assessing LV diastolic dyssynchrony.


Myocardial perfusion imaging: SPECT left ventricular function heart failure phase analysis left ventricular dyssynchrony

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© American Society of Nuclear Cardiology 2011