Major Achievements in Nuclear Cardiology

Journal of Nuclear Cardiology

, Volume 18, Issue 4, pp 685-694

First online:

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

  • Ji ChenAffiliated withDepartment of Radiology and Imaging Sciences, Emory University School of Medicine Email author 
  • , Ernest V. GarciaAffiliated withDepartment of Radiology and Imaging Sciences, Emory University School of Medicine
  • , Jeroen J. BaxAffiliated withDepartment of Cardiology, Leiden University Medical Center
  • , Ami E. IskandrianAffiliated withDivision of Cardiology, University of Alabama at Birmingham
  • , Salvador Borges-NetoAffiliated withDepartment of Radiology, Duke University Medical Center
  • , Prem SomanAffiliated withCardiovascular Institute, University of Pittsburgh Medical Center

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Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or implantable cardioverter defibrillator therapy and in assessing LV diastolic dyssynchrony.


Myocardial perfusion imaging: SPECT left ventricular function heart failure phase analysis left ventricular dyssynchrony