Potential of [11C]acetate for measuring myocardial blood flow: Studies in normal subjects and patients with hypertrophic cardiomyopathy
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Measuring the rate of clearance of carbon-11 labelled acetate from myocardium using positron emission tomography (PET) is an accepted technique for noninvasively assessing myocardial oxygen consumption. Initial myocardial uptake of [11C]acetate, however, is related to myocardial blood flow (MBF) and several tracer kinetic models for quantifying MBF using [11C]acetate have been proposed. The objective of this study was to assess these models.
Eighteen healthy subjects and 18 patients with hypertrophic cardiomyopathy (HCM) were studied under baseline conditions with [11C]acetate and [15O]water. Four previously reported methods, including single- and multi-tissue compartment models, were used to calculate MBF from the measured [11C]acetate rate of influx K 1 and the (previously) reported relationship between K 1 and MBF. These MBF values were then compared with those derived from corresponding [15O]water studies.
For all models, correlations between [11C]acetate and [15O]water-derived MBF ranged from .67 to .86 (all P < .005) in the control group and from .73 to .85 (all P < .001) in the HCM group. Two out of four models systematically underestimated perfusion with [11C]acetate, whilst the third model resulted in an overestimation. The fourth model, based on a simple single tissue compartment model with spillover, partial volume and recirculating metabolite corrections, resulted in a regression equation with a slope of near unity and an Y-intercept of almost zero (controls, K 1 = .74[MBF] + .09, r = .86, SEE = .13, P < .001 and HCM, K 1 = .89[MBF] + .03, r = .85, SEE = .12, P < .001).
[11C]acetate enables quantification of MBF in fairly good agreement with actual MBF in both healthy individuals and patients with HCM. A single tissue compartment model with standardized correction for recirculating metabolites and with corrections for partial volume and spillover provided the best results.
- Armbrecht JJ, Buxton DB, Brunken RC, Phelps ME, Schelbert HR. Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography. Circulation 1989;80:863-72.
- Klein LJ, Visser FC, Knaapen P, et al. Carbon-11 acetate as a tracer of myocardial oxygen consumption. Eur J Nucl Med 2001;28:651-68. CrossRef
- Knaapen P, Germans T, Knuuti J, et al. Myocardial energetics and efficiency: Current status of the noninvasive approach. Circulation 2007;115:918-27. CrossRef
- Buxton DB, Nienaber CA, Luxen A, et al. Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography. Circulation 1989;79:134-42.
- Brown MA, Myears DW, Bergmann SR. Validity of estimates of myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography despite altered patterns of substrate utilization. J Nucl Med 1989;30:187-93.
- Gropler RJ, Siegel BA, Geltman EM. Myocardial uptake of carbon-11-acetate as an indirect estimate of regional myocardial blood flow. J Nucl Med 1991;32:245-51.
- Herrero P, Kim J, Sharp TL, et al. Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET. J Nucl Med 2006;47:477-85.
- Sun KT, Yeatman LA, Buxton DB, et al. Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate. J Nucl Med 1998;39:272-80.
- van den Hoff J, Burchert W, Borner AR, et al. [1-(11)C]Acetate as a quantitative perfusion tracer in myocardial PET. J Nucl Med 2001;42:1174-82.
- Chan SY, Brunken RC, Phelps ME, Schelbert HR. Use of the metabolic tracer carbon-11-acetate for evaluation of regional myocardial perfusion. J Nucl Med 1991;32:665-72.
- Sciacca RR, Akinboboye O, Chou RL, Epstein S, Bergmann SR. Measurement of myocardial blood flow with PET using 1-11C-acetate. J Nucl Med 2001;42:63-70.
- Porenta G, Cherry S, Czernin J, et al. Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging. Eur J Nucl Med 1999;26:1465-74. CrossRef
- Knaapen P, Germans T, Camici PG, et al. Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 2008;294:H986-93. CrossRef
- Knaapen P, Boellaard R, Gotte MJ, et al. Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy. J Nucl Med 2004;45:1299-304.
- Iida H, Kanno I, Takahashi A, et al. Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation 1988;78:104-15.
- Hermansen F, Rosen SD, Fath-Ordoubadi F, et al. Measurement of myocardial blood flow with oxygen-15 labelled water: Comparison of different administration protocols. Eur J Nucl Med 1998;25:751-9. CrossRef
- Buck A, Wolpers HG, Hutchins GD, et al. Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. J Nucl Med 1991;32:1950-7.
- Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-10.
- Armbrecht JJ, Buxton DB, Schelbert HR. Validation of [1-11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Circulation 1990;81:1594-605.
- El Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with 82Rb PET: Comparison with 13N-ammonia. J Nucl Med 2009;50:1062-71. CrossRef
- Cannon RO III, Rosing DR, Maron BJ, et al. Myocardial ischemia in patients with hypertrophic cardiomyopathy: Contribution of inadequate vasodilator reserve and elevated left ventricular filling pressures. Circulation 1985;71:234-43.
- Potential of [11C]acetate for measuring myocardial blood flow: Studies in normal subjects and patients with hypertrophic cardiomyopathy
Journal of Nuclear Cardiology
Volume 17, Issue 2 , pp 264-275
- Cover Date
- Print ISSN
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- Myocardial blood flow
- positron emission tomography
- hypertrophic cardiomyopathy
- Industry Sectors
- Author Affiliations
- 1. Department of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, The Netherlands
- 2. Department of Cardiology, 5F, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
- 3. Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands
- 4. Department of Cardiology, Thorax Centre Erasmus Medical Centre, Rotterdam, The Netherlands