, Volume 17, Issue 1, pp 106-115
Date: 17 Nov 2009

Contrast enhanced ultrasound imaging

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Historic Development

Introduction

The origins of contrast enhanced ultrasound imaging (CEUS) date to the earliest observations of Claude Joyner and publications of Gramiak and Shah in 1968.1 Interest in the development of ultrasound contrast agents and associated clinical applications continues today, nearly 40 years after the first reports.

The use of blood pool agents for enhancement of cardiovascular structures is ubiquitous, current clinical diagnostic imaging modalities utilize contrast agents to define anatomy and quantify tissue perfusion. Specifically, with regard to ultrasound contrast agents, the unique physical properties of air-filled, microspheres serving as true intravascular indicators provide an unparalleled access to the intrinsic spatial and temporal heterogeneity of tissue perfusion.2

Importantly, though initially developed for diagnostic applications, novel therapeutic applications for the ultrasound contrast agents are forthcoming. Thus, while the use of ultrasound con ...