Journal of Nuclear Cardiology

, Volume 17, Issue 1, pp 27–37

Direct comparison of rest and adenosine stress myocardial perfusion CT with rest and stress SPECT

Authors

  • David R. Okada
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Brian B. Ghoshhajra
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Ron Blankstein
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
    • Non-invasive Cardiovascular Imaging Program, Department of Medicine and RadiologyBrigham and Women’s Hospital
  • Jose A. Rocha-Filho
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Leonid D. Shturman
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Ian S. Rogers
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Hiram G. Bezerra
    • Harrington McLaughlin Heart and Vascular InstituteCase Western Reserve University
  • Ammar Sarwar
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
    • Department of RadiologyBeth Israel Deaconess Medical Center and Harvard Medical School
  • Henry Gewirtz
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Udo Hoffmann
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
  • Wilfred S. Mamuya
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
    • Lown Cardiovascular Group
  • Thomas J. Brady
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
    • Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology Massachusetts General Hospital and Harvard Medical School
    • Cardiovascular MR and CT ProgramBaptist Cardiac and Vascular Institute
Original Article

DOI: 10.1007/s12350-009-9156-z

Cite this article as:
Okada, D.R., Ghoshhajra, B.B., Blankstein, R. et al. J. Nucl. Cardiol. (2010) 17: 27. doi:10.1007/s12350-009-9156-z

Introduction

We have recently described a technique for assessing myocardial perfusion using adenosine-mediated stress imaging (CTP) with dual source computed tomography. SPECT myocardial perfusion imaging (SPECT-MPI) is a widely utilized and extensively validated method for assessing myocardial perfusion. The aim of this study was to determine the level of agreement between CTP and SPECT-MPI at rest and under stress on a per-segment, per-vessel, and per-patient basis.

Methods

Forty-seven consecutive patients underwent CTP and SPECT-MPI. Perfusion images were interpreted using the 17 segment AHA model and were scored on a 0 (normal) to 3 (abnormal) scale. Summed rest and stress scores were calculated for each vascular territory and patient by adding corresponding segmental scores.

Results

On a per-segment basis (n = 799), CTP and SPECT-MPI demonstrated excellent correlation: Goodman-Kruskall γ = .59 (P < .0001) for stress and .75 (P < .0001) for rest. On a per-vessel basis (n = 141), CTP and SPECT-MPI summed scores demonstrated good correlation: Pearson r = .56 (P < .0001) for stress and .66 (P < .0001) for rest. On a per-patient basis (n = 47), CTP and SPECT-MPI demonstrated good correlation: Pearson r = .60 (P < .0001) for stress and .76 (P < .0001) for rest.

Conclusions

CTP compares favorably with SPECT-MPI for detection, extent, and severity of myocardial perfusion defects at rest and stress.

Keywords

Adenosinecomputed tomography (CT)ischemiamyocardialsestamibiSPECT

Copyright information

© American Society of Nuclear Cardiology 2009