There are 550,000 new cases of heart failure with 1,000,000 hospitalizations and 250,000 heart failure deaths yearly in the USA with similar numbers in the European Union. Cardiac resynchronization therapy (CRT), based in the placement of A-V sequential, biventricular pacemakers, is indicated to treat patients with advanced, medically refractory heart failure, reduced left ventricular (LV) function, and prolonged QRS duration. Normally stimulated in an orderly pattern, conduction is rapid through normal myocardium, bringing near simultaneous, coordinate, and synchronous myocardial contraction. Scarring leads to irregular conduction and varied sequences of dyssynchronous contraction. CRT, seeks to improve mechanical synchrony, but has other benefits. CRT has been shown to improve symptoms and survival, increase exercise tolerance, and quality of life, reduce hospitalization, and bring reverse remodeling1 in heart failure patients. Yet, there is now nothing better to determine mechanical ...
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- Imaging synchrony
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Journal of Nuclear Cardiology
Volume 16, Issue 6 , pp 846-848
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- 1. Departments of Radiology, Nuclear Medicine Section and Medicine, Cardiovascular Division, University of California San Francisco, San Francisco, CA, USA
- 2. Department of Radiology, Nuclear Medicine Section, University of California San Francisco, San Francisco, CA, USA
- 3. Department of Medicine, Cardiovascular Division, University of California San Francisco, San Francisco, CA, USA