Who gets the heart attack: noninvasive imaging markers of plaque instability
- Jagat Narula MD, PhD
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Acute coronary events result from thrombotic occlusion of the coronary artery.1-5 The occlusion is secondary to rupture of an atherosclerotic plaque in up to three-fourths of subjects; plaque erosion is seen in most of the remaining subjects who have died of an acute coronary event.2 Plaque rupture is associated with traditional risk factors, whereas erosion is generally associated with smoking and is commonly observed in women or younger subjects. Upon histopathological examination, the plaques that are prone to rupture and result in an acute event are almost always large.1-5 Such plaques also demonstrate large necrotic cores that occupy a large proportion of the plaque area. These necrotic cores are often associated with intraplaque neovascularization and hemorrhage, and adventitial vasa vasorum proliferation. 6,7 The necrotic cores are covered by rather attenuated fibrous cap, which are intensely inflamed. Therefore, an imaging strategy designed to identify rupture-prone plaques wou ...
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- Who gets the heart attack: noninvasive imaging markers of plaque instability
Journal of Nuclear Cardiology
Volume 16, Issue 6 , pp 860-868
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- Jagat Narula MD, PhD (1) (2)
- Author Affiliations
- 1. Memorial Heart & Vascular Institute, Long Beach, CA, USA
- 2. University of California, Irvine, Irvine, CA, USA