Clinical Journal of Gastroenterology

, Volume 6, Issue 2, pp 160–163

Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient

Authors

    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Shingo Nakamoto
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Makoto Arai
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Tatsuo Miyamura
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Shuang Wu
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Keiichi Fujiwara
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
  • Osamu Yokosuka
    • Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba University
Case Report

DOI: 10.1007/s12328-013-0366-1

Cite this article as:
Kanda, T., Nakamoto, S., Arai, M. et al. Clin J Gastroenterol (2013) 6: 160. doi:10.1007/s12328-013-0366-1

Abstract

We describe a patient infected with hepatitis C virus (HCV) genotype 1 who failed to respond to interferon with or without ribavirin seven times but who then achieved sustained virological response by the combination of interferon-beta plus ribavirin treatment for 48 weeks. He did not respond to stronger treatment such as prolonged peginterferon plus ribavirin treatment for 87 weeks. It might be rare to treat a patient with interferon 8 times considering the cost and time, since patients failing interferon treatment several times are regarded to be refractory to interferon. It is possible that the difference in biological effects between interferon-alfa and interferon-beta might have resulted in a different outcome in our patient. Interferon-beta plus ribavirin therapy might be one of the treatment options for certain patients chronically infected with HCV who do not respond to standard care treatment.

Keywords

Hepatitis CHCV genotype 1Interferon-betaNeutralizing antibodyRibavirinSustained virological response

Copyright information

© Springer Japan 2013