Clinical Journal of Gastroenterology

, Volume 3, Issue 1, pp 6–12

Premalignant lesions in gastric cancer

  • Kazuo Yashima
  • Shuji Sasaki
  • Masaharu Koda
  • Koichiro Kawaguchi
  • Kenichi Harada
  • Yoshikazu Murawaki
Clinical Review

DOI: 10.1007/s12328-009-0130-8

Cite this article as:
Yashima, K., Sasaki, S., Koda, M. et al. Clin J Gastroenterol (2010) 3: 6. doi:10.1007/s12328-009-0130-8
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Abstract

Despite a plateau in incidence, gastric cancer is one of the most common cancers worldwide and causes considerable morbidity and mortality. Premalignant gastric lesions are well known risk factors for the development of intestinal-type gastric adenocarcinomas. In this multistep model of gastric carcinogenesis, Helicobacter pylori causes chronic active inflammation of the gastric mucosa, which slowly progresses through the premalignant stages of atrophic gastritis, intestinal metaplasia, and adenoma/dysplasia to gastric carcinoma. This progression is paralleled by a stepwise accumulation of multiple genetic and epigenetic abnormalities. Detection, treatment, and molecular analyses of premalignant lesions may thus provide a basis for gastric cancer prevention. This review describes an overview of current knowledge on premalignant gastric lesions. It also reviews the issue of surveillance of patients with premalignant lesions in order to improve the survival of patients with gastric cancer.

Keywords

Helicobacter pylori Atrophic gastritis Intestinal metaplasia Adenoma/dysplasia Gastric cancer 

Copyright information

© Springer 2009

Authors and Affiliations

  • Kazuo Yashima
    • 1
  • Shuji Sasaki
    • 1
  • Masaharu Koda
    • 1
  • Koichiro Kawaguchi
    • 1
  • Kenichi Harada
    • 1
  • Yoshikazu Murawaki
    • 1
  1. 1.Division of Medicine and Clinical Science, Faculty of MedicineTottori UniversityYonagoJapan