Advances in Therapy

, Volume 30, Issue 3, pp 203–211

Linaclotide, Novel Therapy for the Treatment of Chronic Idiopathic Constipation and Constipation-Predominant Irritable Bowel Syndrome


  • Maria I. Vazquez-Roque
    • Division of Gastroenterology and Hepatology, Mayo Clinic
    • Division of Gastroenterology and Hepatology, Mayo Clinic

DOI: 10.1007/s12325-013-0012-9

Cite this article as:
Vazquez-Roque, M.I. & Bouras, E.P. Adv Therapy (2013) 30: 203. doi:10.1007/s12325-013-0012-9


Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal (GI) disorders. Current treatment options, either prescription or nonprescription medications, have limited efficacy in a subset of patients. There is significant demand for more efficacious medications for the treatment of CC and IBS-C. Linaclotide, a secretagogue, has a novel mechanism of action designed to treat patients with CC and IBS-C. It has a low oral bioavailability with negligible systemic side effects, and it acts locally in the intestinal lumen. In several clinical trials, in health and disease, linaclotide has demonstrated durable efficacy and safety in CC and IBS-C. Linaclotide received approval by the Federal Drug Administration in August 2012 to treat chronic idiopathic constipation and IBS-C.


ConstipationGastroenterologyGuanylate cyclase CGuanylinIrritable bowel syndromeLinaclotideUroguanylin
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© Springer Healthcare 2013