, Volume 29, Issue 2, pp 79-98,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 07 Feb 2012

5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

Abstract

Cyclooxygenase (COX)-1, COX-2, and 5-lipoxygenase (5-LOX) enzymes produce effectors of pain and inflammation in osteoarthritis (OA) and many other diseases. All three enzymes play a key role in the metabolism of arachidonic acid (AA) to inflammatory fatty acids, which contribute to the deterioration of cartilage. AA is derived from both phospholipase A2 (PLA2) conversion of cell membrane phospholipids and dietary consumption of omega-6 fatty acids. Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the COX enzymes, but show no anti-5-LOX activity to prevent the formation of leukotrienes (LTs). Cysteinyl LTs, such as LTC4, LTD4, LTE4, and leukoattractive LTB4 accumulate in several organs of mammals in response to NSAID consumption. Elevated 5-LOX-mediated AA metabolism may contribute to the side-effect profile observed for NSAIDs in OA. Current therapeutics under development, so-called “dual inhibitors” of COX and 5-LOX, show improved side-effect profiles and may represent a new option in the management of OA.

To view enhanced content go to www.advancesintherapy.com
This article is published with open access at Springerlink.com