Advances in Therapy

, Volume 27, Issue 6, pp 348–364

Systematic review on evidence of the effectiveness of cholesterol-lowering drugs

  • Abhaya Gupta
  • Veronique Guyomard
  • M. Justin S. Zaman
  • Habib U. Rehman
  • Phyo Kyaw Myint

DOI: 10.1007/s12325-010-0033-6

Cite this article as:
Gupta, A., Guyomard, V., Zaman, M.J.S. et al. Adv Therapy (2010) 27: 348. doi:10.1007/s12325-010-0033-6



Coronary heart disease (CHD) is the leading cause of mortality worldwide. With increasingly urbanized lifestyles in developing countries and the aging populations, the major risk factors for CHD such as obesity, diabetes mellitus, and hypercholesterolemia are likely to increase in the future. In the current report, we reviewed the evidence on the effect of cholesterol lowering using pharmacological agents.


A PubMed/Medline systematic search was performed over the past 12 years (1998–2009 inclusive) and relevant papers written in the English language were selected. We used key phrases including, “risk factors for hypercholesterolemia,” “management of hypercholesterolemia,” “guidelines for management of hypercholesterolemia,” and “pharmacological management of hypercholesterolemia.”


There were a total of over 3500 reports. We selected key publications on the effect of cholesterol lowering using different pharmacological agents.


Several options exist with regards to pharmacological management of hypercholesterolemia. There is a substantial body of evidence to support the effect of a population shift towards a favorable risk profile, which has huge potential in reducing the burden of CHD globally.


cardiovascular diseasecholesterol-lowering drugscoronary heart diseasehypercholesterolemiarisk

Copyright information

© Springer Healthcare 2010

Authors and Affiliations

  • Abhaya Gupta
    • 1
  • Veronique Guyomard
    • 2
  • M. Justin S. Zaman
    • 3
  • Habib U. Rehman
    • 4
  • Phyo Kyaw Myint
    • 5
  1. 1.Department of MedicineWest Wales HospitalCarmarthenUK
  2. 2.Ageing and Stroke Research GroupNorfolk and Norwich University HospitalNorwichUK
  3. 3.University College LondonLondonUK
  4. 4.Regina Qu”Appelle Health RegionReginaCanada
  5. 5.School of Medicine, Health Policy and PracticeUniversity of East AngliaNorwichUK