Advances in Therapy

, Volume 26, Issue 6, pp 588–599

Long-acting risperidone: a review of its role in the treatment of bipolar disorder

  • David E. Kemp
  • Fatih Canan
  • Benjamin I. Goldstein
  • Roger S. McIntyre

DOI: 10.1007/s12325-009-0039-0

Cite this article as:
Kemp, D.E., Canan, F., Goldstein, B.I. et al. Adv Therapy (2009) 26: 588. doi:10.1007/s12325-009-0039-0


Bipolar disorder is a multidimensional illness typified by fluctuating periods of depression and mania, cognitive dysfunction, abnormal circadian rhythms, and multiple comorbid psychiatric and general medical conditions. Indefinite pharmacological treatment is often required, yet the modest effects of available treatments and frequent difficulties with tolerability and adherence present complex challenges to patients. Long-acting injectable medications offer a therapeutic alternative to oral mood stabilizers and may help facilitate long-term treatment adherence. This article will provide a succinct review of the latest data on the use of long-acting injectable risperidone (LAR) during the maintenance-phase treatment of bipolar disorder. The specific role of LAR in comparison to other atypical antipsychotics, and the limitations of available studies will be discussed from the perspectives of efficacy, tolerability, and sequential positioning in treatment guidelines.


adherencebipolar disorderlong-acting risperidonemaintenance phaserisperidone

Copyright information

© Springer Healthcare Communications 2009

Authors and Affiliations

  • David E. Kemp
    • 1
  • Fatih Canan
    • 2
  • Benjamin I. Goldstein
    • 3
  • Roger S. McIntyre
    • 4
  1. 1.Mood & Metabolic Clinic, Case Western Reserve UniversityUniversity Hospitals Case Medical CenterClevelandUSA
  2. 2.Duzce University Medical SchoolDuzceTurkey
  3. 3.Western Psychiatric Institute and ClinicUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Mood Disorders Psychopharmacology Unit, University Health Network, Associate Professor of Psychiatry and PharmacologyUniversity of TorontoTorontoUSA