The Cerebellum

, Volume 13, Issue 1, pp 64–78

Prefrontal Control of Cerebellum-Dependent Associative Motor Learning

  • Hao Chen
  • Li Yang
  • Yan Xu
  • Guang-yan Wu
  • Juan Yao
  • Jun Zhang
  • Zhi-ru Zhu
  • Zhi-an Hu
  • Jian-feng Sui
  • Bo Hu
Original Paper

DOI: 10.1007/s12311-013-0517-4

Cite this article as:
Chen, H., Yang, L., Xu, Y. et al. Cerebellum (2014) 13: 64. doi:10.1007/s12311-013-0517-4

Abstract

Behavioral studies have demonstrated that both medial prefrontal cortex (mPFC) and cerebellum play critical roles in trace eyeblink conditioning. However, little is known regarding the mechanism by which the two brain regions interact. By use of electrical stimulation of the caudal mPFC as a conditioned stimulus, we show evidence that persistent outputs from the mPFC to cerebellum are necessary and sufficient for the acquisition and expression of a trace conditioned response (CR)-like response. Specifically, the persistent outputs of caudal mPFC are relayed to the cerebellum via the rostral part of lateral pontine nuclei. Moreover, interfering with persistent activity by blockade of the muscarinic Ach receptor in the caudal mPFC impairs the expression of learned trace CRs. These results suggest an important way for the caudal mPFC to interact with the cerebellum during associative motor learning.

Keywords

Trace conditioning Prefrontal cortex Persistent activity Cerebellum Interstimulus interval Eyeblink 

Abbreviations

aCSF

Artificial cerebrospinal fluid

CS

Conditioned stimulus

CR

Conditioned response

IN

Interpositus nucleus

ISI

Interstimulus interval

LPN

Lateral pontine nuclei

mPFC

Medial prefrontal cortex

mAchR

Muscarinic Ach receptor

SCOP

Scopolamine hydrobromide

TEBC

Trace eyeblink conditioning

US

Unconditioned stimulus

Supplementary material

12311_2013_517_MOESM1_ESM.pdf (916 kb)
ESM 1(PDF 915 kb)

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hao Chen
    • 1
  • Li Yang
    • 1
  • Yan Xu
    • 1
  • Guang-yan Wu
    • 1
    • 2
  • Juan Yao
    • 1
    • 2
  • Jun Zhang
    • 1
  • Zhi-ru Zhu
    • 1
  • Zhi-an Hu
    • 1
  • Jian-feng Sui
    • 1
    • 2
  • Bo Hu
    • 1
  1. 1.Department of Physiology, College of Basic Medical SciencesThird Military Medical UniversityChongqingChina
  2. 2.Experimental Center of Basic Medicine, College of Basic Medical SciencesThird Military Medical UniversityChongqingChina