The Cerebellum

, Volume 11, Issue 1, pp 1–4

Diversity and Complexity of Roles of Granule Cells in the Cerebellar Cortex. Editorial


DOI: 10.1007/s12311-012-0365-7

Cite this article as:
Manto, M. & De Zeeuw, C.I. Cerebellum (2012) 11: 1. doi:10.1007/s12311-012-0365-7


The cerebellar granule cell, the most numerous neurons in the brain, forms the main excitatory neuron of the cerebellar cortical circuitry. Granule cells are synaptically connected with both mossy fibers and Golgi cells inside specialized structures called glomeruli, and thereby, they are subject to both feed-forward and feed-back inhibition. Their unique architecture with about four dendrites and a single axon ascending in the cerebellar cortex to bifurcate into two parallel fibers making synapses with Purkinje neurons has attracted numerous scientists. Recent advances show that they are much more than just relays of mossy fibers. They perform diverse and complex transformations in the spatiotemporal domain. This special issue highlights novel avenues in our understanding of the roles of this key neuronal population of the cerebellar cortex, ranging from developmental up to physiological and pathological points of view.

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.FNRS-Neurologie, Unité d’Etude du MouvementBruxellesBelgium
  2. 2.Department of NeuroscienceErasmus MCRotterdamThe Netherlands
  3. 3.Netherlands Institute for NeuroscienceRoyal Dutch Academy of Arts & Sciences (KNAW)AmsterdamThe Netherlands