Diversity and Complexity of Roles of Granule Cells in the Cerebellar Cortex. Editorial
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The cerebellar granule cell, the most numerous neurons in the brain, forms the main excitatory neuron of the cerebellar cortical circuitry. Granule cells are synaptically connected with both mossy fibers and Golgi cells inside specialized structures called glomeruli, and thereby, they are subject to both feed-forward and feed-back inhibition. Their unique architecture with about four dendrites and a single axon ascending in the cerebellar cortex to bifurcate into two parallel fibers making synapses with Purkinje neurons has attracted numerous scientists. Recent advances show that they are much more than just relays of mossy fibers. They perform diverse and complex transformations in the spatiotemporal domain. This special issue highlights novel avenues in our understanding of the roles of this key neuronal population of the cerebellar cortex, ranging from developmental up to physiological and pathological points of view.
- Herculano-Houzel S, Lent R. Isotropic fractionator: a simple, rapid method for the quantification of total cell numbers in the brain. J Neurosci. 2005;25:2518–21. CrossRef
- Mugnaini E, Sekerkova G, Martina M. The unipolar brush cell: a remarkable neuron finally receiving deserved attention. Brain Res Rev. 2011;66(1–2):220–45. CrossRef
- Ramon y Cajal S. Sur l’origine et la direction des prolongations nerveuses de la couche moléculaire du cervelet. Internat Mschr Anat Physiol. 1889;7:12–31.
- D’Angelo E. Cerebellar granule cells. In: Manto M, Gruol D, Schmahmann JD, Koibuchi N, Rossi F, editors. Handbook of the cerebellum and cerebellar disorders. Berlin: Springer; 2012.
- Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Hübner CA, De Zeeuw CI, Jentsch TJ. Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J. 2012;doi:10.1038/emboj.2011.488.
- Hamori J, Somogyi J. Differentiation of cerebellar mossy fiber synapses in the rat: a quantitative electron microscope study. J Comp Neurol. 1983;220:365–77. CrossRef
- D’Angelo E, De Zeeuw CI. Timing and plasticity in the cerebellum: focus on the granular layer. Trends Neurosci. 2009;32(1):30–40. CrossRef
- Eccles JC, Ito M, Szentagothai J. The cerebellum as a neural machine. Berlin: Springer; 1967.
- Kistler WM, De Zeeuw CI. Time windows and reverberating loops: a reverse-engineering approach to cerebellar function. Cerebellum. 2003;2:44–54. CrossRef
- Canterini S, Bosco A, Carletti V, Fuso A, Curci A, Mangia F, Fiorenza MT. Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation. Cerebellum. 2012; in press.
- Kilpatrick DL, Wang W, Gronostajski R, Litwack ED. Nuclear factor I and cerebellar granule neuron development: an intrinsic-extrinsic interplay. Cerebellum. 2012; in press.
- Contestabile A. Role of nitric oxide in cerebellar development and function: focus on granule neurons. Cerebellum. 2012; in press.
- Courjaret R, Miras-Portugal MT, Deitmer JW. Purinergic modulation of granule cells. Cerebellum. 2012; in press.
- Hirano T. Glutamate-receptor-like molecule GluRdelta2 involved in synapse formation at parallel fiber-Purkinje neuron synapses. Cerebellum. 2012; in press.
- Matsuda K, Yuzaki M. Cbln1 and the Delta2 glutamate receptor—an orphan ligand and an orphan receptor find their partners. Cerebellum. 2012; in press.
- Saftenku EE. Models of calcium dynamics in cerebellar granule cells. Cerebellum. 2012. In press.
- Saftenku EE. Effects of calretinin on Ca(2+) signals in cerebellar granule cells: implications of cooperative Ca(2+) binding. Cerebellum. 2012; in press.
- Zhang W, Linden DJ. Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers. Cerebellum. 2012; in press.
- Strackx E, Gantert M, Moers V, van Kooten IA, Rieke R, Hürter H, Lemmens MA, Steinbusch HW, Zimmermann LJ, Vles JS, Garnier Y, Gavilanes AW, Kramer BW. Increased number of cerebellar granule cells and astrocytes in the internal granule layer in sheep following prenatal intra-amniotic injection of lipopolysaccharide. Cerebellum. 2012; in press.
- Luo J. Mechanisms of ethanol-induced death of cerebellar granule cells. Cerebellum. 2012; in press.
- Hall CN, Garthwaite J. What is the real physiological NO concentration in vivo? Nitric Oxide. 2009;21:92–103. CrossRef
- Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, et al. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol. 2003;163(2):295–302. CrossRef
- Brockhaus J, Dressel D, Herold S, Deitmer JW. Purinergic modulation of synaptic input to Purkinje neurons in rat cerebellar brain slices. Eur J Neurosci. 2004;19(8):2221–30. CrossRef
- Dar MS, Mustafa SJ. Acute ethanol/cannabinoid-induced ataxia and its antagonism by oral/systemic/intracerebellar A1 adenosine receptor antisense in mice. Brain Res. 2002;957(1):53–60. CrossRef
- Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, Takayama C, et al. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell. 1995;81(2):245–52. CrossRef
- Kato A, Yoshida T, Himeshima Y, Mishina M, Hirano T. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate delta2 subunit or Purkinje cells. Eur J Neurosci. 2005;21(5):1315–26. CrossRef
- Lalouette A, Lohof A, Sotelo C, Guénet J, Mariani J. Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor. Neuroscience. 2001;105(2):443–55. CrossRef
- Le Guen MC, De Zeeuw CI. Presynaptic plasticity at cerebellar parallel fiber terminals. Funct Neurol. 2010;25(3):141–51.
- Lahra MM, Jeffery HE. A fetal response to chorioamnionitis is associated with early survival after preterm birth. Am J Obstet Gynecol. 2004;190(1):147–51. CrossRef
- Gilles FH, Averill Jr DR, Kerr CS. Neonatal endotoxin encephalopathy. Ann Neurol. 1977;2(1):49–56. CrossRef
- Koziol LF, Budding DE, Chidekel D. Adaptation, expertise, and giftedness: towards an understanding of cortical, subcortical, and cerebellar network contributions. Cerebellum. 2010;9(4):499–529. CrossRef
- Manto M. Cerebellar disorders. A practical approach to diagnosis and management. Cambridge: Cambride University Press; 2010. CrossRef
- Diversity and Complexity of Roles of Granule Cells in the Cerebellar Cortex. Editorial
Volume 11, Issue 1 , pp 1-4
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. FNRS-Neurologie, Unité d’Etude du Mouvement, 808 Route de Lennik, 1070, Bruxelles, Belgium
- 2. Department of Neuroscience, Erasmus MC, 3015 GE, Rotterdam, The Netherlands
- 3. Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts & Sciences (KNAW), 1105 BA, Amsterdam, The Netherlands