The Cerebellum

, Volume 9, Issue 2, pp 232–239

Falls in Spinocerebellar Ataxias: Results of the EuroSCA Fall Study

  • Ella M. R. Fonteyn
  • Tanja Schmitz-Hübsch
  • Carla C. Verstappen
  • Laslo Baliko
  • Bastiaan R. Bloem
  • Silvia Boesch
  • Lisa Bunn
  • Perrine Charles
  • Alexandra Dürr
  • Allesandro Filla
  • Paola Giunti
  • Christoph Globas
  • Thomas Klockgether
  • Bela Melegh
  • Massimo Pandolfo
  • Anna De Rosa
  • Ludger Schöls
  • Dagmar Timmann
  • Marten Munneke
  • Berry P. H. Kremer
  • Bart P. C. van de Warrenburg
Article

DOI: 10.1007/s12311-010-0155-z

Cite this article as:
Fonteyn, E.M.R., Schmitz-Hübsch, T., Verstappen, C.C. et al. Cerebellum (2010) 9: 232. doi:10.1007/s12311-010-0155-z

Abstract

To investigate the frequency, details, and consequences of falls in patients with autosomal dominant spinocerebellar ataxias (SCAs) and to derive specific disease-related risk factors that are associated with an increased fall frequency. Two hundred twenty-eight patients with SCA1, SCA2, SCA3, or SCA6, recruited from the EuroSCA natural history study, completed a fall questionnaire that assessed the frequency, consequences, and several details of falls in the previous 12 months. Relevant disease characteristics were retrieved from the EuroSCA registry. The database of the natural history study provided the ataxia severity scores as well as the number and nature of non-ataxia symptoms. Patients (73.6%) reported at least one fall in the preceding 12 months. There was a high rate of fall-related injuries (74%). Factors that were associated with a higher fall frequency included: disease duration, severity of ataxia, the presence of pyramidal symptoms, the total number of non-ataxia symptoms, and the genotype SCA3. Factors associated with a lower fall frequency were: the presence of extrapyramidal symptoms (more specifically dystonia of the lower limbs) and the genotype SCA2. The total number of non-ataxia symptoms and longer disease duration were independently associated with a higher fall frequency in a logistic regression analysis, while the presence of extrapyramidal symptoms was independently associated with a lower fall frequency. Our findings indicate that, in addition to more obvious factors that are associated with frequent falls, such as disease duration and ataxia severity, non-ataxia manifestations in SCA play a major role in the fall etiology of these patients.

Keywords

AtaxiaSCAFallsPyramidalInjuries

Supplementary material

12311_2010_155_MOESM1_ESM.doc (48 kb)
ESM 1Dutch Questionnaire (DOC 48 kb)
12311_2010_155_MOESM2_ESM.doc (54 kb)
ESM 2English Questionnaire (DOC 54 kb)
12311_2010_155_MOESM3_ESM.doc (52 kb)
ESM 3French Questionnaire (DOC 52 kb)
12311_2010_155_MOESM4_ESM.doc (48 kb)
ESM 4German Questionnaire (DOC 47 kb)

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ella M. R. Fonteyn
    • 1
  • Tanja Schmitz-Hübsch
    • 2
  • Carla C. Verstappen
    • 3
  • Laslo Baliko
    • 4
  • Bastiaan R. Bloem
    • 1
  • Silvia Boesch
    • 5
  • Lisa Bunn
    • 6
  • Perrine Charles
    • 7
    • 8
  • Alexandra Dürr
    • 7
    • 8
  • Allesandro Filla
    • 9
  • Paola Giunti
    • 6
  • Christoph Globas
    • 10
  • Thomas Klockgether
    • 2
  • Bela Melegh
    • 11
  • Massimo Pandolfo
    • 12
  • Anna De Rosa
    • 9
  • Ludger Schöls
    • 10
  • Dagmar Timmann
    • 13
  • Marten Munneke
    • 1
  • Berry P. H. Kremer
    • 14
  • Bart P. C. van de Warrenburg
    • 1
    • 15
  1. 1.Department of Neurology (935)Radboud University Nijmegen Medical CentreNijmegenThe Netherlands
  2. 2.Department of NeurologyUniversity Hospital of BonnBonnGermany
  3. 3.Department of NeurologyCanisius Wilhelmina HospitalNijmegenThe Netherlands
  4. 4.Department of Neurology and StrokeCounty HospitalVeszprémHungary
  5. 5.Department of NeurologyUniversity of InnsbruckInnsbruckAustria
  6. 6.Department of Molecular NeuroscienceInstitute of NeurologyLondonUK
  7. 7.INSERM, UMR_S679 Neurologie and Thérapeutic ExpérimenteleAp-HP, Hôpital de la Pitié-SalpêtrièreParisFrance
  8. 8.Départment of GeneticsCytogenetics and Embryology, Salpetriere HospitalParisFrance
  9. 9.Department of NeurologyUniversity of NaplesNaplesItaly
  10. 10.Department of Neurology and Hertie-Institute for Clinical Brain ResearchUniversity of TübingenTubingenGermany
  11. 11.Department of Medical Genetics and Child DevelopmentUniversity of PécsPécsHungary
  12. 12.Department of Neurology, Hôpital ErasmeUniversité Libre de BruxellesBrusselsBelgium
  13. 13.Department of NeurologyUniversity of Duisburg-EssenEssenGermany
  14. 14.Department of NeurologyUniversity Medical Centre GroningenGroningenThe Netherlands
  15. 15.Donders Institute for Brain, Cognition and BehaviourCentre for NeuroscienceNijmegenThe Netherlands