The Cerebellum

, 7:494

Gluten ataxia

  • Marios Hadjivassiliou
  • David S. Sanders
  • Nicola Woodroofe
  • Claire Williamson
  • Richard A. Grünewald
Invited Review

DOI: 10.1007/s12311-008-0052-x

Cite this article as:
Hadjivassiliou, M., Sanders, D.S., Woodroofe, N. et al. Cerebellum (2008) 7: 494. doi:10.1007/s12311-008-0052-x

Abstract

Gluten ataxia is an immune-mediated disease triggered by the ingestion of gluten in genetically susceptible individuals. It should be considered in the differential diagnosis of all patients with idiopathic sporadic ataxia. Early diagnosis and treatment with a gluten free diet can improve ataxia and prevent its progression. Readily available and sensitive markers of gluten ataxia include antigliadin antibodies. IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis.

Key words

Gluten ataxiacerebellum

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Marios Hadjivassiliou
    • 1
    • 4
  • David S. Sanders
    • 2
  • Nicola Woodroofe
    • 3
  • Claire Williamson
    • 3
  • Richard A. Grünewald
    • 1
  1. 1.Department of NeurologyThe Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS TrustSheffieldUK
  2. 2.Department of GastroenterologyThe Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS TrustSheffieldUK
  3. 3.Department of Biomedical ScienceSheffield Hallam UniversitySheffieldUK
  4. 4.Department of NeurologyThe Royal Hallamshire HospitalSheffieldUK