, Volume 5, Issue 4, pp 291-296
Date: 04 Jan 2012

CD68+ cell numbers and dendritic cell numbers and phenotype fail to predict the presence of a MYC rearrangement in aggressive B-cell lymphomas

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Abstract

MYC rearrangements are frequently associated with aggressive B-cell lymphomas, such as Burkitt’s lymphoma. We sought surrogate markers of MYC rearrangements that might obviate the need for a complex and expensive technique such as fluorescent in situ hybridization (FISH). We show that numbers of CD68+ macrophages/dendritic cells (DCs), DC-SIGN+ myeloid DCs and CD123+ plasmacytoid DCs fail to correlate with MYC rearrangement, although a starry sky appearance shows positive correlation (p = 0.003) when statistical analysis is performed on all three diagnostic groups together. We conclude that FISH is required to investigate the presence of a MYC rearrangement in cases of aggressive B-cell lymphoma, in order to guide the chemotherapeutic regime offered to the patient.