Journal of Hematopathology

, Volume 5, Issue 4, pp 291–296

CD68+ cell numbers and dendritic cell numbers and phenotype fail to predict the presence of a MYC rearrangement in aggressive B-cell lymphomas

  • Sandrine Gaslain
  • Marie Stolbrink
  • Margaret Jones
  • Elizabeth J. Soilleux
Original Article

DOI: 10.1007/s12308-011-0125-5

Cite this article as:
Gaslain, S., Stolbrink, M., Jones, M. et al. J Hematopathol (2012) 5: 291. doi:10.1007/s12308-011-0125-5
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Abstract

MYC rearrangements are frequently associated with aggressive B-cell lymphomas, such as Burkitt’s lymphoma. We sought surrogate markers of MYC rearrangements that might obviate the need for a complex and expensive technique such as fluorescent in situ hybridization (FISH). We show that numbers of CD68+ macrophages/dendritic cells (DCs), DC-SIGN+ myeloid DCs and CD123+ plasmacytoid DCs fail to correlate with MYC rearrangement, although a starry sky appearance shows positive correlation (p = 0.003) when statistical analysis is performed on all three diagnostic groups together. We conclude that FISH is required to investigate the presence of a MYC rearrangement in cases of aggressive B-cell lymphoma, in order to guide the chemotherapeutic regime offered to the patient.

Keywords

Burkitt’s lymphomaDiffuse large B-cell lymphomaMYCTranslocationRearrangementHistiocyteMacrophageDendritic cellCD68DC-SIGNCD123

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Sandrine Gaslain
    • 1
  • Marie Stolbrink
    • 2
  • Margaret Jones
    • 3
  • Elizabeth J. Soilleux
    • 1
    • 3
  1. 1.Department of Cellular PathologyJohn Radcliffe HospitalOxfordUK
  2. 2.Oxford University Medical SchoolOxfordUK
  3. 3.Nuffield Department of Clinical Laboratory SciencesUniversity of OxfordOxfordUK