, Volume 6, Issue 1, pp 25-32
Date: 15 Dec 2011

Donor-derived isolated del(20q) after hematopoietic stem cell transplantation: report of two cases and review of the literature

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Introduction

Clonal cytogenetic abnormalities in a host following hematopoietic stem cell transplantation (HSCT) are usually of host origin, and their presence typically indicates the onset of myelodysplastic syndrome (MDS) or acute leukemia. Rarely, clonal cytogenetic abnormalities are of donor origin and are usually associated with a donor cell neoplasm, either MDS or leukemia. Although uncommon, most reported cases of donor cell MDS have had unequivocal clinical and/or morphologic findings of MDS associated with clonal cytogenetic abnormalities, most often involving chromosome 7, X, or 16 [115]. Rare patients have been reported, however, with a clonal karyotype derived from donor cells who did not develop clinical disease with follow-up as long as 50 months [16].

Deletion of the long arm of chromosome 20, del(20q), is a frequent abnormality in various hematologic conditions, including myeloproliferative neoplasms and MDS [17]. Isolated del(20q) in MDS is associated with mild cytopeni