Journal of Hematopathology

, Volume 3, Issue 1, pp 19–22

NK cell lymphoma, nasal type, with massive lung involvement: a case report

  • Anamarija Morovic
  • Igor Aurer
  • Snjezana Dotlic
  • Dennis D. Weisenburger
  • Marin Nola
Case Report

DOI: 10.1007/s12308-009-0050-z

Cite this article as:
Morovic, A., Aurer, I., Dotlic, S. et al. J Hematopathol (2010) 3: 19. doi:10.1007/s12308-009-0050-z

Abstract

Extranodal NK/T cell lymphoma, nasal type, is an Epstein–Barr virus-associated lymphoma that most commonly involves the nasal cavity and upper respiratory tract. Lung involvement by NK/T cell lymphoma is rare and seldom reported in the literature. We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma.

Keywords

Extranodal NK/T lymphomaLung involvementEpstein–Barr virus

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Anamarija Morovic
    • 1
  • Igor Aurer
    • 2
  • Snjezana Dotlic
    • 4
  • Dennis D. Weisenburger
    • 3
  • Marin Nola
    • 4
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of Internal MedicineZagreb University Hospital CenterZagrebCroatia
  3. 3.Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  4. 4.Department of PathologyZagreb University Hospital CenterZagrebCroatia