Cancer Microenvironment

, Volume 4, Issue 3, pp 377–392

Immune Cells in Colorectal Cancer: Prognostic Relevance and Role of MSI

  • Vanessa Deschoolmeester
  • Marc Baay
  • Filip Lardon
  • Patrick Pauwels
  • Marc Peeters
Article

DOI: 10.1007/s12307-011-0068-5

Cite this article as:
Deschoolmeester, V., Baay, M., Lardon, F. et al. Cancer Microenvironment (2011) 4: 377. doi:10.1007/s12307-011-0068-5

Abstract

There is growing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of solid tumors. Colorectal cancer (CRC) results from the cumulative effect of sequential genetic alterations, leading to the expression of tumor-associated antigens possibly inducing a cellular anti-tumor immune response. It is well recognized that cytotoxic lymphocytes (CTLs) constitute one of the most important effector mechanisms of anti-tumor-immunity. However, their potential prognostic influence in CRC remains controversial. In addition, other key players like natural killer cells, tumor associated macrophages and regulatory T cells play an important role in the immune attack against CRC and need further investigation. This review will mainly focus on the role of the adaptive immune system in CRC and particularly in regard to microsatellite instability.

Keywords

Colorectal cancerImmune responseT lymphocytesMicrosatellite instability

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Vanessa Deschoolmeester
    • 1
  • Marc Baay
    • 1
  • Filip Lardon
    • 1
  • Patrick Pauwels
    • 1
  • Marc Peeters
    • 1
  1. 1.Laboratory of Cancer Research and Clinical OncologyUniversity of AntwerpWilrijkBelgium