Indian Journal of Clinical Biochemistry

, Volume 28, Issue 1, pp 19–23

Mucosal IgA & IL-1β in Helicobacter pylori Infection

  • Ragini Srivastava
  • Antara Kashyap
  • Mohan Kumar
  • Gopal Nath
  • Ashok Kumar Jain
Original Article

DOI: 10.1007/s12291-012-0262-3

Cite this article as:
Srivastava, R., Kashyap, A., Kumar, M. et al. Ind J Clin Biochem (2013) 28: 19. doi:10.1007/s12291-012-0262-3

Abstract

Helicobacter pylori infection stimulates strong local inflammatory and specific IgA antibody production. The influence of antibodies on the bacterial colonization is not clear. Here, we have analysed the association between the mucosal IgA level and IL-1β in various manifestations of the infection seen endoscopically. Antral biopsies of 57 dyspeptic patients were taken for culture, histology and estimation of mucosal levels of anti-H. pylori IgA and IL-1β. Mean mucosal IgA level was higher in patients with normal mucosa compared to all other groups and lower IgA level was associated with higher bacterial density. IL-1β was higher in ulcer patients and suspicious malignancy group as compared to normal group and higher level of IL-1β was associated with higher grades of metaplasia. Present study indicates that local immunity seems to have a protective role against H. pylori infection and higher level of IL-1β induced by the pathogen may be associated with metaplasia and carcinogenesis.

Keywords

H. pyloriIgAIL-1βLocal immunity

Supplementary material

12291_2012_262_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 kb)
12291_2012_262_MOESM2_ESM.docx (1.2 mb)
Supplementary material 2 (DOCX 1245 kb)

Copyright information

© Association of Clinical Biochemists of India 2012

Authors and Affiliations

  • Ragini Srivastava
    • 1
  • Antara Kashyap
    • 1
  • Mohan Kumar
    • 2
  • Gopal Nath
    • 3
  • Ashok Kumar Jain
    • 4
  1. 1.Department of Biochemistry, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of Pathology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  3. 3.Department of Microbiology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  4. 4.Department of Gastroenterology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia