Indian Journal of Clinical Biochemistry

, Volume 26, Issue 4, pp 360–365

Efficacy of a Fish Protein Hydrolysate in Malnourished Children


  • Knut Olav Nesse
    • Zymtech Production AS
  • A. P. Nagalakshmi
    • Consortium Clinical Research Pvt. Ltd
  • P. Marimuthu
    • Department of BiostatisticsNational Institute of Mental Health and Neuro Sciences (NIMHANS)
    • Jamia Milia Islamia
    • Plant Pathology DivisionIndian Agricultural Research Institute, Pusa Campus
Original Article

DOI: 10.1007/s12291-011-0145-z

Cite this article as:
Nesse, K.O., Nagalakshmi, A.P., Marimuthu, P. et al. Ind J Clin Biochem (2011) 26: 360. doi:10.1007/s12291-011-0145-z


Protein hydrolysates are good nutritional supplements as their bioactive ingredients can be easily absorbed and utilized for various metabolic activities. A fish protein hydrolysate (Amizate), prepared by a unique process of hydrolysis has the advantage of high di/tri peptide content (<10 kDa) along with essential and non essential amino acids, micronutrients and vitamins. The effect of Amizate on malnourished children (6–8 years, a total of 438) of Grade I and II (Gomez’s classification) with respect to immunoglobulins, CD4/CD8 ratios and hemoglobin was examined. Measurement of these parameters during the user trial study (at the beginning and the end after 4 months) indicated that the levels of the immunological parameters were not significantly altered by the Amizate treatment. The values of immunoglobulins and CD4/CD8 ratios of malnourished children (India) are in the normal range and are in accordance with the reported values of various ethnic groups.


Protein hydrolysatesImmunoglobulinMalnourishmentNutrition

Supplementary material

12291_2011_145_MOESM1_ESM.ppt (606 kb)
Supplementary material 1 (PPT 603 kb)

Copyright information

© Association of Clinical Biochemists of India 2011