Original Article

Indian Journal of Clinical Biochemistry

, Volume 26, Issue 4, pp 360-365

First online:

Efficacy of a Fish Protein Hydrolysate in Malnourished Children

  • Knut Olav NesseAffiliated withZymtech Production AS
  • , A. P. NagalakshmiAffiliated withConsortium Clinical Research Pvt. Ltd
  • , P. MarimuthuAffiliated withDepartment of Biostatistics, National Institute of Mental Health and Neuro Sciences (NIMHANS)
  • , Mamta SinghAffiliated withJamia Milia IslamiaPlant Pathology Division, Indian Agricultural Research Institute, Pusa Campus Email author 

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Protein hydrolysates are good nutritional supplements as their bioactive ingredients can be easily absorbed and utilized for various metabolic activities. A fish protein hydrolysate (Amizate), prepared by a unique process of hydrolysis has the advantage of high di/tri peptide content (<10 kDa) along with essential and non essential amino acids, micronutrients and vitamins. The effect of Amizate on malnourished children (6–8 years, a total of 438) of Grade I and II (Gomez’s classification) with respect to immunoglobulins, CD4/CD8 ratios and hemoglobin was examined. Measurement of these parameters during the user trial study (at the beginning and the end after 4 months) indicated that the levels of the immunological parameters were not significantly altered by the Amizate treatment. The values of immunoglobulins and CD4/CD8 ratios of malnourished children (India) are in the normal range and are in accordance with the reported values of various ethnic groups.


Protein hydrolysates Immunoglobulin Malnourishment Nutrition