Indian Journal of Clinical Biochemistry

, Volume 25, Issue 2, pp 188–192

Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats

Authors

    • Department of BiochemistrySohag University
    • Sohag Faculty of MedicineSohag University
    • Department of Biochemistry, Sohag faculty of MedicineSohag University
  • M. A. Ibrahim
    • Department of PharmaceuticsSohag University
    • El-Azhar Faculty of pharmacyElazhar University (Assiut)
  • N. S. Ahmed
    • Department of BiochemistrySohag University
    • Sohag Faculty of MedicineSohag University
  • M. A. Abdelaziz
    • Department of BiochemistrySohag University
    • El-Azhar Faculty of pharmacyElazhar University (Assiut)
Original Article

DOI: 10.1007/s12291-010-0034-x

Cite this article as:
Abdelmoaty, M.A., Ibrahim, M.A., Ahmed, N.S. et al. Indian J Clin Biochem (2010) 25: 188. doi:10.1007/s12291-010-0034-x

Abstract

Quercetin (QE), one of natural flavanoid group, was widely distributed as a secondary metabolite in plant kingdom. It has been believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus (DM). The aim of the present study was the evaluation of possible effects of QE on blood glucose and antioxidant enzymes in experimental streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally with single dose of 50 mg/kg for diabetes induction. QE (15 mg/kg bw day, intraperitoneal (i.p.) injection) was injected for 3 days prior to STZ administration; these injections were continued to the end of the study (for 25 days). Glucose tolerance test and random plasma glucose were done for all animals. Cellular antioxidant enzymes such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were measured in pancreatic homogenates. Quercetin had no effect on plasma glucose level of normal animals but its pre- treatment was able to prevent diabetes induced by single intraperitoneal injection of streptozocintreated rats. Antioxidant enzyme activity significantly decreased in STZ induced diabetic group. QE treatment significantly increased the antioxidant enzyme activities. It could be concluded that quercetin, a flavonoid with antioxidant properties, exerting its beneficial antidiabetic effects.

Key Words

QuercetinFlavonoidAntioxidantAntidiabetic
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© Association of Clinical Biochemists of India 2010