Abstract
The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri — iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Heuck CC, Kallner A, Kanagasabapathy AS, Riesen W. WHO Document (WHO/DIL /00.4) on “Diagnosis and monitoring of diseases of the thyroid”, 2000.
Cooper DS. Clinical practice: Subclinical Hypothyroidism. N Engl J Med 2001; 345: 260–265.
Cooper DS. Subclinical hypothyroidism. JAMA 1987; 258: 246–247.
Surks MI, Ortiz E, Daniels GH, Sawin CT, Cobin RH. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management, JAMA 2004; 291: 228–238.
Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489–499.
Col NF, Surks MI, Daniels GH. Subclinical thyroid disease: clinical applications. JAMA 2004; 291:239–243.
Lock RJ, Marden NA, Kemp HJ, Thomas PH, Goldie DJ, Gompels MM. Subclinical Hypothyroidism: a comparison of strategies to achieve adherence to treatment guidelines Ann Clin Biochem 2004; 41: 197–200.
Samuels MH. Subclinical thyroid disease in the elderly. Thyroid 1998; 8: 803–813.
Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, Braverman LE. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab 2002; 87: 3221–3226.
Kumar A, Chaturvedi PK, Mohanty BP. Hypoandrogenaemia is associated with subclinical hypothyroidism in men. Int J Androl 2007; 30: 14–20.
Mishra TK, Routray SN, Das S, Behera M. Left ventricular dysfunction in patients with subclinical hypothyroidism and its reversibility after hormone therapy. J Assoc Phys India 2005; 53: 943–946.
Marwaha RK, Tandon N, Karak AK, Gupta N, Verma K, Kochupillai N. Hashimoto’s Thyroiditis: Countrywide Screening of Goitrous Healthy Young Girls in Postiodization Phase in India. J Clin Endocrinol Met 2000; 85: 3798–3802.
Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K. Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Met 1994; 78: 393–397.
Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, et al. Effect of lodine Intake on Thyroid Diseases in China. N Engl J Med 2006;354: 2783–2793.
Shan ZY, Li YS, Wang ZY, Jin Y, Guan HX, Hu FN, et al. Effect of different iodine intake on school children’s thyroid diseases and intelligence in rural areas. Chin Med J 2005; 117:1518–1522.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mohanty, S., Amruthlal, W., Reddy, G.C. et al. Diagnostic strategies for subclinical hypothyroidism. Indian J Clin Biochem 23, 279–282 (2008). https://doi.org/10.1007/s12291-008-0062-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12291-008-0062-y