Indian Journal of Hematology and Blood Transfusion

, Volume 30, Issue 2, pp 139–142

Chronic Neutrophilic Leukemia with V617F JAK2 Mutation

Authors

  • Smeeta Gajendra
    • Laboratory Oncology UnitDr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)
    • Laboratory Oncology UnitDr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)
  • Meenal Chandgothia
    • Laboratory Oncology UnitDr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)
  • Lalit Kumar
    • Department of Medical OncologyDR. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)
  • Richa Gupta
    • Laboratory Oncology UnitDr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)
  • Snehal Motilal Chavan
    • Acton Biotech (I) Pvt. Ltd
Case Report

DOI: 10.1007/s12288-012-0203-6

Cite this article as:
Gajendra, S., Gupta, R., Chandgothia, M. et al. Indian J Hematol Blood Transfus (2014) 30: 139. doi:10.1007/s12288-012-0203-6

Abstract

Chronic neutrophilic leukemia (CNL) is a rare disease grouped under World health organization classification as chronic myeloproliferative disease. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative disease or reactive neutrophilia. V617F JAK 2 mutation has been described in classical myeloproliferative diseases, but its association with CNL has been reported in a few cases. Here in, we describe three cases of CNL with presence of V617F JAK 2 mutation. To distinguish CNL from secondary neutrophilia can be difficult. Detection of the V617F JAK 2 mutation in such scenario can provide a useful diagnostic test to establish the neoplastic nature of the neutrophilia.

Keywords

Chronic myeloproliferative diseaseChronic neutrophilic leukemiaV617F JAK 2 mutation

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2012