Case Report

Indian Journal of Hematology and Blood Transfusion

, Volume 29, Issue 3, pp 173-177

First online:

Successful Management of Chronic Refractory Immune Thrombocytopenia with Laparoscopic Splenectomy in a Patient with Acute Promyelocytic Leukemia

  • Ahmet Emre EskazanAffiliated withDepartment of Hematology, Diyarbakir Training and Research Hospital Email author 
  • , Ayse SalihogluAffiliated withDivision of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University
  • , Emine GulturkAffiliated withDivision of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University
  • , Seniz Ongoren AydinAffiliated withDivision of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University
  • , Nukhet TuzunerAffiliated withDepartment of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University
  • , Yildiz AydinAffiliated withDivision of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University

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Abstract

Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.

Keywords

Immune thrombocytopenia ITP Splenectomy Acute promyelocytic leukemia APL