Indian Journal of Hematology and Blood Transfusion

, Volume 28, Issue 3, pp 162–169

Morphologic Changes in the Bone Marrow in Patients of Chronic Myeloid Leukemia (CML) Treated with ImatinibMesylate

  • B. H. Srinivas
  • T. Roshni Paul
  • Shantveer G. Uppin
  • Megha S. Uppin
  • Rachel T. Jacob
  • D. Raghunadharao
Original Article

DOI: 10.1007/s12288-011-0136-5

Cite this article as:
Srinivas, B.H., Paul, T.R., Uppin, S.G. et al. Indian J Hematol Blood Transfus (2012) 28: 162. doi:10.1007/s12288-011-0136-5

Abstract

Imatinib mesylate (Gleevec) is an effective treatment for chronic myeloid leukemia (CML). Though cytogenetic and molecular analyses are essential disease monitoring parameters in CML bone marrow morphological response is not well defined. We examined marrow samples from 40 patients with CML which have at least 2 or more follow-up marrow. A significant positive correlation with complete cytogenetic response shown for normalization of cellularity (P = 0.0097), absence of dry tap (P = 0.0368) and abnormal megakaryocytes (P = 0.005), reduction of blasts (P = 0.019), basophils (P = 0.031), M:E index (P = 0.018) and fibrosis (P = 0.018). Morphological criteria for complete cytogenetic response in CML patients treated with Imatinib can be defined.Morphologic response is also of potential clinical value in addition to cytogenetic and molecular response in patients of CML treated with Imatinib.

Keywords

Morphology Bone marrow Chronic myeloid leukemia Imatinib mesylate 

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2012

Authors and Affiliations

  • B. H. Srinivas
    • 1
  • T. Roshni Paul
    • 1
  • Shantveer G. Uppin
    • 1
  • Megha S. Uppin
    • 1
  • Rachel T. Jacob
    • 1
  • D. Raghunadharao
    • 2
  1. 1.Department of PathologyNizam’s Institute of Medical SciencesHyderabadIndia
  2. 2.Department of Medical OncologyNizam’s Institute of Medical SciencesHyderabadIndia