Indian Journal of Hematology and Blood Transfusion

, Volume 24, Issue 4, pp 182–185

Systemic mastocytosis with acute myelomonocytic leukemia: a case report

Case Report

DOI: 10.1007/s12288-008-0044-5

Cite this article as:
Kar, R., Rao, S. & Pati, H.P. Indian J Hematol Blood Transfus (2008) 24: 182. doi:10.1007/s12288-008-0044-5


Bone marrow mastocytosis may be associated with many clonal non mast cell hematological neoplasms and its association with acute myeloid leukemia especially with t (8; 21) has been described. We describe an interesting case of coexistence of systemic mastocytosis with acute myelomonocytic leukemia in a young child. Diagnosis of acute myelomonocytic leukemia was based on bone marrow aspirate findings coupled with cytochemistry. Systemic mastocytosis was diagnosed on the basis of bone marrow biopsy findings showing blasts as well as multifocal dense mast cell infiltrates with spindling and atypical morphology which was confirmed on toluidine blue staining.


Acute myeloid leukemiaToluidine blueSystemic mastocytosis

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2008

Authors and Affiliations

  1. 1.Department of HematologyAll India Institute of Medical SciencesNew DelhiIndia